NEW EFFECTIVE TERMINAL DIFFERENTIATION-INDUCING AGENT AND ITS USE

Title:

NEW EFFECTIVE TERMINAL DIFFERENTIATION-INDUCING AGENT AND ITS USE

Document Type and Number:

Japanese Patent JP2003226680

Kind Code:

A

Abstract:

To provide a method for selectively inducing the terminal differentiation of tumor cells and thereby inhibiting the propagation of the cells, and a method for treating a patient having the tumor cells in the propagation.

This compound is expressed by formula (1) [wherein, R1, R2 are each independently cycloalkylamino, pyridineamino, piperidino, 9-purine-6- amine or thiazoleamino when the R1, R2 are same; and R1=R3-N-R4, each of R3, R4 are H, hydroxyl, an alkyl, an alkenyl, a cycloalkyl, an aryl, an alkyloxy, an aryloxy, an arylalkyloxy or pyridine, or R3 and R4 are bonded each other to form a piperidine, and R2 is hydroxylamino, hydroxyl, amino, an alkylamino, or an alkyoxy, when the R1, R2 are different; and (n) is 4-8 integer].

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Inventors:

BRESLOW RONALD (US)
MARKS PAUL A (US)
RIFKIND RICHARD A (US)
JURSIC BRANKO (US)

Application Number:

JP2002337049A

Publication Date:

August 12, 2003

Filing Date:

October 05, 1992

Export Citation:

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Assignee:

SLOAN KETTERING INST CANCER (US)
UNIV COLUMBIA (US)

International Classes:

A61K31/16; A61K31/164; A61K31/165; A61K31/167; A61K31/192; A61K31/197; A61K31/20; A61K31/216; A61K31/221; A61K31/275; A61K31/277; A61K31/425; A61K31/426; A61K31/427; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/445; A61K31/4453; A61K31/52; A61P35/00; A61P35/02; A61P43/00; C07C229/24; C07C229/30; C07C233/05; C07C233/06; C07C233/07; C07D295/18; C07C233/15; C07C233/25; C07C233/34; C07C233/36; C07C233/43; C07C233/54; C07C233/64; C07C233/92; C07C237/04; C07C237/42; C07C255/19; C07C255/42; C07C255/44; C07C255/60; C07C259/06; C07C259/08; C07C259/10; C07C271/10; C07C271/28; C07C275/28; C07D211/16; C07D211/26; C07D211/32; C07D213/56; C07D213/75; C07D277/02; C07D277/20; C07D277/44; C07D277/46; C07D295/185; C07D487/04; C07D519/00; (IPC1-7): C07C233/05; A61K31/16; A61K31/165; A61K31/167; A61K31/192; A61K31/20; A61K31/216; A61K31/275; A61K31/277; A61K31/427; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4453; A61K31/52; A61P35/00; A61P35/02; A61P43/00; C07C233/06; C07C233/07; C07C233/15; C07C233/64; C07C255/60; C07C259/06; C07D211/16; C07D213/75; C07D277/20; C07D277/46; C07D487/04

Attorney, Agent or Firm:

Takehiko Suzue (2 outside)

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