Title:
CDDOメチルエステルの新規形態
Document Type and Number:
Japanese Patent JP5005812
Kind Code:
B2
Abstract:
A triterpenoid compound, methyl 2-cyano-3,12-dioxo-Ieana- 1,9(11)-dien-28-oate (CDDO methyl ester), has a crystalline, glassy solid form and a non-hydrous crystalline form that can prepared, for example, from a saturated methanol solution. The glassy form displays an enhanced bioavailability over the non-hydrous crystalline form. Each form of CDDO methyl ester is a superior candidate for use, typically in solid dosage form, for treating a variety of disease states, generally associated with inflammation.
Inventors:
Walling, John
Parent, Stephan, Dee.
Jonaitis, David, Tee.
Clar. Robert, M.
Parent, Stephan, Dee.
Jonaitis, David, Tee.
Clar. Robert, M.
Application Number:
JP2010521031A
Publication Date:
August 22, 2012
Filing Date:
August 14, 2008
Export Citation:
Assignee:
Riata Pharmaceuticals, Inc.
International Classes:
C07J63/00; A61K31/56; A61K47/32; A61K47/38; A61P1/00; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P35/00; A61P37/02
Foreign References:
| US20030119732 |
Other References:
J. Med. Chem.,2000年,Vol.43, No.22,p.4233-4246
経口投与製剤の設計と評価,1995年 2月10日,p.172-179
Acta Crystallographica, Section C,2002年,Vol.C58, No.3,p.o119-o200
経口投与製剤の設計と評価,1995年 2月10日,p.172-179
Acta Crystallographica, Section C,2002年,Vol.C58, No.3,p.o119-o200
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Ishii Teiji
Satoshi Fujita
Eiichi Arai