Title:
新規融合体及びその検出法
Document Type and Number:
Japanese Patent JP6806440
Kind Code:
B2
Abstract:
Provided are: a detection method in which fusions (fusion proteins and fusion genes that encode the fusion proteins), which are new causative agents of cancer, are elucidated, and new fusions and derivatives are detected on the basis of the results; a kit and primer set for the aforementioned detection method; a method for screening inhibitors of the expression and/or activity of polypeptides which are the fusion proteins; and pharmaceutical compositions, which contain the aforementioned inhibitors, for treating cancer. The fusion proteins comprise ZSCAB9 fusion proteins or ALK fusion proteins. In the screening method, the fusion proteins or fusion genes that encode the fusion proteins are detected in a sample obtained from a subject.
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Inventors:
Kengo Takeuchi
Yuki Togashi
Seiji Sakata
Naoya Fujita
Katayama Ryohei
Yuki Togashi
Seiji Sakata
Naoya Fujita
Katayama Ryohei
Application Number:
JP2015545257A
Publication Date:
January 06, 2021
Filing Date:
October 29, 2014
Export Citation:
Assignee:
Cancer Research Society
International Classes:
C12N15/62; C07K14/435; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/12; C12Q1/6876; G01N33/53; G01N33/574
Domestic Patent References:
| JP2009100783A |
Foreign References:
| WO2011043220A1 | ||||
| WO2006109943A1 |
Other References:
Clinical Cancer Research,2008年,Vol.14, No.20,p.6618-6624
Clinical Cancer Research,2009年,Vol.15, No.9,p.3143-3149
Biochemical Journal,2009年,Vol.420,p.345-361
Clinical Cancer Research,2009年,Vol.15, No.9,p.3143-3149
Biochemical Journal,2009年,Vol.420,p.345-361
Attorney, Agent or Firm:
Kenjiro Yamaguchi
Kenichi Morita
Kenichi Morita