Title:
新規なグリカンコンジュゲートおよびその使用方法
Document Type and Number:
Japanese Patent JP6779887
Kind Code:
B2
Abstract:
The present disclosure is directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA3/SSEA4/GloboH associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globo-series glycosphingolipid synthesis. The present disclosure relates to methods and compositions which can modulate the globo-series glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globo-series glycosphingolipid SSEA3/SSEA4/GloboH in the biosynthetic pathway; particularly, the glycoenzyme inhibitors target the alpha-4GalT; beta-4GalNAcT-I; or beta-3GalT-V enzymes in the globo-series synthetic pathway. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.
Inventors:
Wong, Ji Fei
Woo, Chun-i
Woo, Chun-i
Application Number:
JP2017538643A
Publication Date:
November 04, 2020
Filing Date:
August 21, 2015
Export Citation:
Assignee:
ACADEMIA SINICA
International Classes:
A61K39/385; A61K47/61; A61P35/00; C08B37/00
Domestic Patent References:
| JP2011524417A | ||||
| JP2017525714A |
Other References:
The Journal of Biological Chemistry,2010年,Vol.285, No.46,p.36049-36059
PNAS,2013年,Vol.110, No.7,p.2517-2522
Journal of the American Chemical Society,2014年,Vol.136,p.16844-16853
PNAS,2013年,Vol.110, No.7,p.2517-2522
Journal of the American Chemical Society,2014年,Vol.136,p.16844-16853
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto