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Title:
NEW GLYCOSYL DONOR AND METHOD OF GLYCOSYLATION
Document Type and Number:
Japanese Patent JPH0733792
Kind Code:
A
Abstract:

PURPOSE: To obtain a new glycosyl donor simply, in high yield and high selectivity by reacting an acyltetraalkylglycopyranoside with a trimethylsilyl ether of an alcohol in the presence of a catalytic amount of an acidic catalyst.

CONSTITUTION: (A) A 1-O-acyl-2,3,4,6-tetra-O-alkyl-D-glycopyranoside is reacted with (B) a trimethylsilyl ether of an alcohol in the presence of a catalytic amount of a Lewis acid or a mixed catalyst of a lewis acid and silver perchlorate or silver trifluoromethanesulfonate in an ether-based solvent to give an α-D- glycopyranoside derivative or /9-D-glucopyranoside derivative of respectively formura I or formula II (R; benzyl, p-methoxybenzyl, etc.) (e.g. 1-O- cyclohexyl-2,3,4,6-tetra-O-benzyl-D-glucopyranose).


Inventors:
Mukoyama, Mitsuaki
Matsubara, Hiroteru
Sasaki, Takenori
Application Number:
JP1993000203733
Publication Date:
February 03, 1995
Filing Date:
July 27, 1993
Export Citation:
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Assignee:
ASAHI CHEM IND CO LTD
International Classes:
B01J27/10; B01J31/26; C07B61/00; C07H1/00; C07H13/04; C07H15/04; C07H15/18; C07J17/00; (IPC1-7): C07H1/00; B01J27/10; B01J31/26; C07H13/04; C07H15/04; C07H15/18; C07J17/00
Attorney, Agent or Firm:
清水 猛 (外2名)



 
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