PURPOSE: To obtain a new hexapeptide which has a specified amino acid sequence, has ligand binding specificity of the leukocyte response integrin expressed by human neutrophils and specifically inhibits phagocytosis increase mediated by the leukocyte response integrin.
CONSTITUTION: Amino acids as constituent components are protected with N terminal protective groups such as carbobenzoyloxy groups or t- butyloxycarbonyl groups and such a series of coupling reactions as to add the amino acids to an extending peptide chain in the desired order are carried out to synthesize a protected peptide chain on a solid-phase substrate such as a p-methylbenzhydrylamine polymer by the conventional peptide solid-phase synthesis method. The peptide chain is then cleaved from the substrate by the action of a cleaving reagent such as trifluoroacetic acid and all the protective groups are removed to obtain the objective hexapeptide having the amino acid sequence of the formula and having ligand binding specificity of the leukocyte response integrin expressed by human neutrophils.
ERITSUKU JIYOERU BURAUN
HATSUTEII DAADEN GURETSUSHIYAM
