Title:
New highly efficient enzyme which changed the substrate specificity of human beta* hexosaminidase B, and gave protease resistance
Document Type and Number:
Japanese Patent JPWO2014061735
Kind Code:
A1
Abstract:
野生型ヒトβ-ヘキソサミニダーゼのα-サブユニット由来の活性を有し、且つ、プロテアーゼに対する抵抗性を有する、ヒトβ-ヘキソサミニダーゼの改変型βサブユニットの提供。野生型ヒトβ-ヘキソサミニダーゼのβ-サブユニットのアミノ酸配列において、第312番目〜第318番目のアミノ酸が、それぞれ順に、グリシン、セリン、グルタミン酸、プロリン、セリン、グリシン、及び、トレオニンに置換されているアミノ酸配列を含む、タンパク質。
Inventors:
Takashi Ito
Sakuraba Hitoshi
Daisuke Tsuji
Sakuraba Hitoshi
Daisuke Tsuji
Application Number:
JP2014542171A
Publication Date:
September 05, 2016
Filing Date:
October 17, 2013
Export Citation:
Assignee:
Tokushima University
Meiji Pharmaceutical University
lsip fund management limited liability company
Meiji Pharmaceutical University
lsip fund management limited liability company
International Classes:
C12N15/09; A61K38/46; A61K48/00; A61P25/00; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/88
Domestic Patent References:
| JP2012522809A | 2012-09-27 |
Foreign References:
| WO2010082622A1 | 2010-07-22 |
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Nobuto Oki
Satoshi Fujita
Nobuto Oki
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