新規ヒト癌・精巣抗原及びその遺伝子

Japanese Patent JP4503801

B2

The present invention provides a cancer/testis antigen which is applicable to diagnosis and immunotherapy for cancer, that is to say, to provide a cancer/testis antigen which is not expressed in normal tissues other than the testis, which is expressed in various cancers over a broad range and which induces immune response in a host, and to provide a caner/testis gene encoding the cancer/testis antigen, etc. By using the yeast Two-hybrid System, the present inventors screened a protein which specifically binds to GCF, a previously reported transcription factor, cloned a gene of a protein specifically binding to the GCF, confirmed that the D40 protein as a resulting gene product is a cancer/testis antigen which is expressed substantially only in the testis in normal human tissues whereas in cancers it is expressed in human primary cancers over a broad range derived from various tissues and cells, and found that the D40 shows high affinity with HLA and has a plurality of sequences comprising 9 or 10 amino acid residues and binding to HLA.

Takimoto Masato
Kuzumaki Akira
Noboru Sato
Hiromasa Sahara

JP2000274218A

July 14, 2010

September 08, 2000

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Japan Science and Technology Agency

A01K67/027; C07K7/06; A61K38/00; A61K39/395; A61K45/00; A61P35/00; A61P37/04; A61P37/06; C07K14/47; C07K14/82; C07K16/32; C07K19/00; C12N1/15; C12N1/19; C12N1/21; C12N5/07; C12N5/0781; C12N5/0783; C12N5/09; C12N5/10; C12N15/09; C12P21/08; C12Q1/02; C12Q1/68; G01N33/15; G01N33/50; A61K39/00; C12R1/91

Oncogene, 7th SEP 2000, Vol.19, p.4446-4450
Database DDBJ/EMBL/GenBank,URL,http://www.ncbi.nlm.nih.gov/sviewer/viewer.fcgi?9716487:OLD02:1189896

Masaki Hirota

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