Title:
新規な免疫異常性疾患予防・治療用剤
Document Type and Number:
Japanese Patent JP4422330
Kind Code:
B2
Abstract:
A prophylactic/remedy for immunopathy for immunopathy comprising, as an active ingredient, modifications of Staphylococcal enterotoxin B (SEB) with substitution of at least one amino acid residues within the amino acid sequence of natural type SEB, or derivatives thereof, wherein said SEB modifications or derivatives thereof have inhibitory activity on T cell activation wherein they interact with specific V beta component of T cell receptor (TCR) but are reduced in their immunological responsiveness to SEB without inducing elimination of T cells having specific V beta component, the elimination being normally induced by natural type SEB or recombinant wild-type SEB.
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Inventors:
Takumi Sasaki
Kazuhiko Kurumi
Soejima is wonderful
Yumi Kimura
Shuei Nozaki
Yoshihide Fujiyama
Kazuhiko Kurumi
Soejima is wonderful
Yumi Kimura
Shuei Nozaki
Yoshihide Fujiyama
Application Number:
JP2000531186A
Publication Date:
February 24, 2010
Filing Date:
February 15, 1999
Export Citation:
Assignee:
Institute for Chemistry and Serum Therapy
Kowa Co., Ltd.
Kowa Co., Ltd.
International Classes:
A61K39/09; A61K38/00; A61K38/16; A61K39/085; A61P29/00; A61P37/02; A61P37/06; C07K14/31; C07K14/315; C12N15/09
Domestic Patent References:
| JP9110704A | ||||
| JP8500328A |
Other References:
John W. et al,Mutations Defining Functional Regionsof the Superantigen Staphylococcal Enterotoxin B,J. Exp. Med.,1992年,Vol.175,pp.387-396
Attorney, Agent or Firm:
Kyousei Tamura
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka
Samejima Mutsumi
Nagatoshi Shinagawa
Yasushi Morimoto
Shinichiro Yamanaka