NEW INDOLE DERIVATIVE AND ITS SALT - Toyama Chemical Co., Ltd.

Title:

NEW INDOLE DERIVATIVE AND ITS SALT

Document Type and Number:

Japanese Patent JP3178880

Kind Code:

B2

Abstract:

PURPOSE: To obtain a new indole derivative extremely useful as an anti-cancer medicine, showing cytodical action on cancerous cells.
CONSTITUTION: A compound of formula I [R1 is H, carboxyl, lower alkyl, alkenyl, cycloalkyl, aryl, acyl or heterocyclmc group; R2 is H, carbamoyl, lower alkyl, aryl, aralkyl or acyl; R3 is H, halogen, OH, lower alkyl, alkenyl, cycloalkyl or aryl; Y is direct bond or lower alkylene; Z is halogen, OH, NR4R5 (R4 and R5 are H, amino-protecting group, lower alkyl, cycloalkyl, aralkyl, acyl, aryl or are bonded together with N linked to form heterocyclic), trialkylammonio or group of formula II] and a salt thereof such as N-(2- dimethylaminoethyl)3,7-dimethyl-2-phenylindole-4,5-carboximide. The compound of formula I wherein R2 is H is obtained by reacting a compound of formula III with a compound of the formula H2N-Y-Z.

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Inventors:

Shun Nagai
Isao Meikan
Keiji Funaki
Yoko Nomura
Mizutani Masatoshi
Takako Hori

Application Number:

JP3861592A

Publication Date:

June 25, 2001

Filing Date:

January 29, 1992

Export Citation:

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Assignee:

Toyama Chemical Co., Ltd.

International Classes:

A61K31/40; A61K31/00; A61K31/407; A61P35/00; C07D487/04; (IPC1-7): C07D487/04

Other References:

Ｊ．Ｃｈｅｍ．Ｓｏｃ．，ＰｅｒｋｉｎＴｒａｎｓ．，Ｉ，Ｖｏｌ．１９７３，Ｎｏ．２１（１９７３），ｐｐ．２４５０−２４５３

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