Title:
New low-molecular quantity cationic lipid for oligonucleotide delivery
Document Type and Number:
Japanese Patent JP5957646
Kind Code:
B2
Abstract:
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain to enhance the efficiency and tolerability of in vivo delivery of siRNA.
Inventors:
Buzz, Brian Davryu
Collective, Stephen El
Davis, Jennifer Earle
Hills, Ivory Day
Cyfried, Dara Day
Stanton, Machine G
Collective, Stephen El
Davis, Jennifer Earle
Hills, Ivory Day
Cyfried, Dara Day
Stanton, Machine G
Application Number:
JP2013513262A
Publication Date:
July 27, 2016
Filing Date:
May 31, 2011
Export Citation:
Assignee:
Sirna Therapeutics,Inc.
International Classes:
C07C217/28; A61K9/127; A61K31/713; A61K47/18; C07D205/04; C07D295/088
Domestic Patent References:
| JP2008501729A |
Foreign References:
| US20090285881 |
Other References:
PHILIPPE BISSEL,"Heptopus", a Novel Class of Amphiphiles with Seven Alkyl Chains. Synthesis and Monolayer Property,LANGMUIR,1999年,15 (5),P1791-1795
Il Farmaco,2004年,Vol.59, No.11,p.869-878
Il Farmaco,2004年,Vol.59, No.11,p.869-878
Attorney, Agent or Firm:
Makoto Ono