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Title:
新規マラリアワクチン
Document Type and Number:
Japanese Patent JP5748658
Kind Code:
B2
Abstract:
The present invention provides a vaccine for preventing and/or treating Plasmodium falciparum infections, which comprises a polypeptide set forth in SEQ ID NO: 1 or represented by formula (1), and an adjuvant. €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒX 1 -A-B-X 2 -Y-X 3 -(Y)n-X 4 -(Y)n-X 5 €ƒ€ƒ€ƒ€ƒ€ƒ(1) (In the formula, X 1 represents the 1st to 7th amino acid residues in a polypeptide set forth in SEQ ID NO: 1; X 2 represents the 73th to 177th amino acid residues; X 3 represents the 178th to 258th amino acid residues; X 4 represents the 259th to 289th amino acid residues; X 5 represents the 290th to 334th amino acid residues; A represents an 8-mer repeat sequence contained in a 47-kd region of SERA polypeptide of Plasmodium falciparum; B represents a sequence of a serine-rich region contained in a 47-kd region of SERA polypeptide of Plasmodium falciparum; Y represents any one selected from A-A, A-B, and B; and n is an integer of 0 or 1.)

Inventors:
Toshihiro Horii
Ken Ishii
Tokihiro Togishi
Application Number:
JP2011511479A
Publication Date:
July 15, 2015
Filing Date:
April 30, 2010
Export Citation:
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Assignee:
National University Corporation Osaka University
International Classes:
A61K39/00; A61K39/39; A61P33/06; C07K14/445; C07K16/20; C12N15/09
Foreign References:
WO2002059319A12002-08-01
WO2006061965A12006-06-15
Other References:
JPN6010045050; 堀井俊宏: '新規ワクチンの開発状況と期待"マラリアワクチン"' 日本臨床 Vol.66,No.10, 200810, P.1990-1998
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office



 
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