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Title:
NEW METHOD FOR RESOLUTION OF ENANTIOMER OF (3,4-DIMETHOXY-BICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL)NITRILE, AND APPLICATION IN SYNTHESIS OF IVABRADINE
Document Type and Number:
Japanese Patent JP2013237675
Kind Code:
A
Abstract:

To provide a method for optical resolution of (3,4-dimethoxy-bicyclo[4.2.0]octa-1,3,5-trien-7-yl)nitrile, and to provide a method for synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid and of their hydrates.

There is provided: a method for optical resolution of a compound represented by formula (I) by chiral chromatography; and application in the synthesis of ivabradine, of its addition salts with a pharmaceutically acceptable acid or of their hydrates.


Inventors:
Lerestif, Jean-michel
Lecouve, Jean-pierre
Dron, Daniel
Gojon, Eric
Phan, Maryse
Application Number:
JP2013000129363
Publication Date:
November 28, 2013
Filing Date:
June 20, 2013
Export Citation:
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Assignee:
LAB SERVIER
International Classes:
C07C253/34; C07C213/02; C07C217/58; C07C255/47; C07D223/16; C07B57/00; C07B61/00
Domestic Patent References:
JPS491550A1974-01-08
JPS59139361A1984-08-10
JP2005298480A2005-10-27
JP2010505110A2010-02-18
JP2007510630A2007-04-26
JP2005330263A2005-12-02
JPH05213890A1993-08-24
JP2010065032A2010-03-25
JPS491550A1974-01-08
JPS59139361A1984-08-10
JP2005298480A2005-10-27
JP2010505110A2010-02-18
JP2007510630A2007-04-26
Foreign References:
Other References:
JPN6012025995; 実験化学講座22 有機合成IV 4版, 19941110, 210頁, 丸善株式会社
JPN6012025996; '擬似移動層方式クロマト' クロマト分離について , 20010122, オルガノ株式会社
JPN6012025995; 実験化学講座22 有機合成IV 4版, 19941110, 210頁, 丸善株式会社
JPN6012025996; '擬似移動層方式クロマト' クロマト分離について , 20010122, オルガノ株式会社
Attorney, Agent or Firm:
特許業務法人 津国
津国 肇
柳橋 泰雄
伊藤 佐保子
小澤 圭子
三宅 俊男
小國 泰弘
田中 洋子
生川 芳徳
柴田 明夫
齋藤 房幸