N-〔(S)-1-カルボキシブチル〕-(S)-アラニンエステルの新規合成方法及びペリンドプリルの合成における適用

Title:

N-〔(S)-1-カルボキシブチル〕-(S)-アラニンエステルの新規合成方法及びペリンドプリルの合成における適用

Document Type and Number:

Japanese Patent JP3872344

Kind Code:

B2

Abstract:

A stereoselective process for the industrial synthesis of compounds of formula (I):wherein R represents linear or branched (C1-C6)alkyl, andapplication in the synthesis of perindopril and pharmaceutically acceptable salts thereof.

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Inventors:

Svi, Jean-Claude
Alain Renault

Application Number:

JP2001556822A

Publication Date:

January 24, 2007

Filing Date:

April 10, 2001

Export Citation:

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Assignee:

Réra Bora Toir Servier

International Classes:

A61K38/55; C07C227/32; A61P9/00; A61P9/04; A61P9/12; A61P43/00; C07B61/00; C07C227/42; C07C229/16; C07C229/24

Domestic Patent References:

JP1110652A

Other References:

M.Vincent et al.,Stereoselective synthesis of a new perhydroindole derivative of chiral iminodiacid,,Tetrahedron Letters,1982年,Vol.23,No.16,p.1677-1680
緒方章,化学実験操作法上巻,株式会社南江堂,1963年,p.41-42

Attorney, Agent or Firm:

Hajime Tsukuni
Fumio Shinoda

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