NEW METHOD FOR SYNTHESIZING IVABRADINE AND ADDITION SALT THEREOF WITH PHARMACOLOGICALLY ACCEPTABLE ACID

Title:

NEW METHOD FOR SYNTHESIZING IVABRADINE AND ADDITION SALT THEREOF WITH PHARMACOLOGICALLY ACCEPTABLE ACID

Document Type and Number:

Japanese Patent JP2010241809

Kind Code:

A

Abstract:

To provide a method for synthesizing a racemic or optically active ivabradine and its addition salt with a pharmacologically acceptable acid, and an intermediate for use in synthesizing ivabradine.

There is provided the method for synthesizing a compound (ivabradine) represented by formula (VII) by allowing a compound represented by formula (VIII) to react with an amine compound in the presence of a salt of a transition metal or of a lanthanoid in a solvent to obtain an intermediate and subsequently converting the resulting intermediate into the compound (ivabradine) represented by formula (VII) by virtue of a hydride donor. In formula (VII), R represents a hydrogen atom or a methyl group.

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Inventors:

PEGLION JEAN-LOUIS
DESSINGES AIME
SERKIZ BERNARD

Application Number:

JP2010076768A

Publication Date:

October 28, 2010

Filing Date:

March 30, 2010

Export Citation:

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