Title:
NEW METHOD
Document Type and Number:
Japanese Patent JP3850692
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To provide a method of preparing a cephalosporin compound and an intermediate for preparation of these compound.
SOLUTION: This method cyclizes a compound of formula (III) to obtain a compound expressed by formula (II). [R1 is H, a methoxy or formamide group; R2 is an acryl group; CO2R3 is a carboxyl group or a carboxylic acid salt anion or a carboxy protecting group; R4 is H, an alkyl group, alkenyl group, alkynyl group, alkoxy group, hydroxyl group, halogen atom, amino group or the like; X is S, SO, SO2, O or CH2: m is 1 or 2; dotted line means that the compound (II) and (III) can be 2- or 3-cephem based compound and in the case of a substituent R4 is not H then the hydrogen atoms bonding to carbon atoms in the side chain may be substituted].
Inventors:
Desmond John Best
George Burton
Brian Charles Gasson
Neil Frederick Osborne
Graham Walker
George Burton
Brian Charles Gasson
Neil Frederick Osborne
Graham Walker
Application Number:
JP2001233551A
Publication Date:
November 29, 2006
Filing Date:
August 01, 2001
Export Citation:
Assignee:
Pfizer Inc.
International Classes:
C07D501/04; A61P31/04; C07D463/06; C07D463/16; C07D501/00; C07D501/20; C07D501/24; C07D501/26; C07D501/60; C07D505/06; C07D505/16; C07D505/18; (IPC1-7): C07D501/04; C07D501/26; C07D501/60
Other References:
Richard L. Elliott et al.,Cycloadditions of Cephalosporin. ,J. Org. Chem.,米国,American Chemical Society,1997年,Vol.62,No.15,4998-5016
Attorney, Agent or Firm:
Kazuo Shamoto
Shosuke Imai
Tadashi Masui
Yasushi Kobayashi
Hiroyuki Tomita
Kiyoshi Murakami
Shosuke Imai
Tadashi Masui
Yasushi Kobayashi
Hiroyuki Tomita
Kiyoshi Murakami