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Title:
フェニルシクロプロピルアミン誘導体の新規調製方法及びチカグレロルを調製するためのそれらの使用
Document Type and Number:
Japanese Patent JP2013530209
Kind Code:
A
Abstract:
Provided herein are novel processes for the preparation of phenylcyclopropylamine derivatives, which are useful intermediates in the preparation of triazolo[4,5-d]pyrimidine compounds. Provided particularly herein are novel, commercially viable and industrially advantageous processes for the preparation of a substantially pure ticagrelor intermediate, trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine. Provided further herein are novel acid addition salts of trans-(1R,2S)-2-(3,4-difluorophenyl)-cyclopropylamine, and process for their preparation. The intermediate and its acid addition salts are useful for preparing ticagrelor, or a pharmaceutically acceptable salt thereof, in high yield and purity.

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Inventors:
Kyle Anil Shahazy
Neia Vignes
Trivedy Niquil
Pradan Nitin Sharad Chandra
Application Number:
JP2013517587A
Publication Date:
July 25, 2013
Filing Date:
June 28, 2011
Export Citation:
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Assignee:
Actavis Group PTC EF
International Classes:
C07C209/56; C07C209/88; C07C211/37; C07B57/00
Domestic Patent References:
JP2003535093A2003-11-25
JP2010500344A2010-01-07
JPH0967312A1997-03-11
Other References:
JPN5013008140; ＳＨＩＮＹＡ　ＭＩＭＡＳＵ: 'ＳＴＲＵＣＴＵＲＡＬＬＹ　ＤＥＳＩＧＮＥＤ　ＴＲＡＮＳ-２-ＰＨＥＮＹＬＣＹＣＬＯＰＲＯＰＹＬＡＭＩＮＥ　ＤＥＲＩＶＡＴＩＶＥＳ　ＰＯＴＥＮＴＬＹ　以下備考' ［ＯＮＬＩＮＥ］ , 20100622, Ｐ１-１５
JPN5013008139; ＦＩＬＬＥＲ　Ｒ．: 'ＮＥＷ　ＲＥＡＣＴＩＯＮＳ　ＯＦ　ＰＯＬＹＦＬＵＯＲＯＡＲＯＭＡＴＩＣ　ＣＯＭＰＯＵＮＤＳ．　　ＰＡＲＴ　ＩＩ．　ＰＯＬＹＦＬＵＯＲＯＡＲＡＬＫＹＬ　ＡＭＩＮＥＳ' ＪＯＵＲＮＡＬ　ＯＦ　ＴＨＥ　ＣＨＥＭＩＣＡＬ　ＳＯＣＩＥＴＹ，　ＳＥＣＴＩＯＮ　Ｃ：　ＯＲＧＡＮＩＣ　ＣＨＥＭＩＳＴＲＹ , 19710101, Ｐ２０６２-２０６８, ＣＨＥＭＩＣＡＬ　ＳＯＣＩＥＴＹ
Attorney, Agent or Firm:
Mikio Yoshimiya



 
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