Title:
新規なメチル化カテキン及びそれを含む組成
Document Type and Number:
Japanese Patent JP5128826
Kind Code:
B2
Abstract:
A novel methylated catechin is provided which has stronger antiallergic activity than conventionally known methylated catechins such as epigallocatechin-3-O-(3-O-methyl)gallate and epigallocatechin-3-O-(4-O-methyl)gallate. The epigallocatechin-3-O-gallate derivative is represented by the chemical formula I:
(wherein R 1 to R 6 are each a hydrogen atom or a methyl group, and at least three of R 1 to R 6 are methyl groups) or an isomer thereof.
Inventors:
Mari Yamamoto
Masanobu Kirita
Taiki Honma
Toyoda Yokota
Masanobu Kirita
Taiki Honma
Toyoda Yokota
Application Number:
JP2007028419A
Publication Date:
January 23, 2013
Filing Date:
February 07, 2007
Export Citation:
Assignee:
Centro Internacional de Agricultura Tropical
Asahi Group Holdings, Ltd.
Asahi Group Holdings, Ltd.
International Classes:
C07D311/62; A23L1/30; A61K8/49; A61K31/353; A61P37/08; A61Q1/00; A61Q5/00; A61Q19/00; C12P17/06
Foreign References:
| WO2004052873A1 | ||||
| WO2006054500A1 |
Other References:
WAN Sheng Biao et al.,Regiospecific and enantioselective synthesis of methylated metabolites of tea catechins,Tetrahedron,2006年,62(25),pp.5897-5904,化合物13
YANASE Emiko et al.,Synthesis of Methyl Derivatives of Epigallocatechin Gallate (EGCg) amd Their Stabilities,ITE Letters on Batteries,New Technologies & Medicine,2005年,6(1),pp.34-37,化合物(4)
ZAVERI Nurulain T.,Synthesis of a 3,4,5-Trimethoxybenzoyl Ester Analogue of Epigallocatechin-3-gallate(EGCG):A Potentia,ORGANIC LETTERS,2001年,3(6),pp843-846,化合物13
PARK Ki Duk et al.,Anticancer activity of 3-O-acyl and alkyl-(-)-epicatechin derivatives,Bioorganic & Medicinal Chemistry Letters,2004年,14(20),pp.5189-5192,化合物SR13192、SR13193
YANASE Emiko et al.,Synthesis of Methyl Derivatives of Epigallocatechin Gallate (EGCg) amd Their Stabilities,ITE Letters on Batteries,New Technologies & Medicine,2005年,6(1),pp.34-37,化合物(4)
ZAVERI Nurulain T.,Synthesis of a 3,4,5-Trimethoxybenzoyl Ester Analogue of Epigallocatechin-3-gallate(EGCG):A Potentia,ORGANIC LETTERS,2001年,3(6),pp843-846,化合物13
PARK Ki Duk et al.,Anticancer activity of 3-O-acyl and alkyl-(-)-epicatechin derivatives,Bioorganic & Medicinal Chemistry Letters,2004年,14(20),pp.5189-5192,化合物SR13192、SR13193
Attorney, Agent or Firm:
Mizuno Katsufumi
Masayuki Kishida
Hiroshin Takano
Masayuki Kishida
Hiroshin Takano