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Title:
NEW NITRIC OXIDE-RELEASING AMIDINE- AND ENAMINE-DERIVED DIAZENIUMDIOLATE, COMPOSITION AND USE THEREOF AND METHOD OF PRODUCING THE SAME
Document Type and Number:
Japanese Patent JP2010168390
Kind Code:
A
Abstract:

To provide a chemical structural framework having an atomic and electronic arrangement whose bonded N2O2-functional group is usable as a spontaneous NO and/or NO-donor.

There are provided nitric oxide-releasing amidine- or enamine-derived diazeniumdiolates, having a chemical structure bond represented by the formula. As a representative example, an acetamidine-tetrakis (nitric oxide) adduct can be cited.


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Inventors:
HRABIE JOSEPH A
KEEFER LARRY K
Application Number:
JP2010050987A
Publication Date:
August 05, 2010
Filing Date:
March 08, 2010
Export Citation:
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Assignee:
US GOVERNMENT
International Classes:
C07C291/02; A61K31/13; C07D295/06; A61K31/136; A61K31/155; A61K31/40; A61K31/4164; A61K31/4453; A61K31/5375; A61K33/00; A61P9/12; A61P25/00; A61P43/00; C07C251/08; C07C291/08; C07D211/72; C07D233/20; C07D233/24; C07D295/023; C07D295/12; C07D295/13; C07D405/04
Domestic Patent References:
JPH07502265A1995-03-09
Foreign References:
WO1996040665A11996-12-19
Other References:
JPN6012033190; Ｉｚｖｅｓｔｉｙａ　Ｓｉｂｉｒｓｋｏｇｏ　Ｏｔｄｅｌｅｎｉｙａ　Ａｋａｄｅｍｉｉ　Ｎａｕｋ　ＳＳＳＲ，　Ｓｅｒｉｙａ　Ｋｈｉｍｉｃｈｅｓｋｉｋｈ　Ｎａｕｋ （４）, 1976, ｐ．１３６-１４０
Attorney, Agent or Firm:
Takashima Ichi
Kyoko Doi
Mitsunori Kamata
Yaeko Tamura
Kenji Yamamoto
Murata Miyuki



 
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