Title:
【発明の名称】新たな寄生蠕虫蛋白質
Document Type and Number:
Japanese Patent JPH08505772
Kind Code:
A
Abstract:
The present invention relates to isolated parasitic helminth nucleic acid sequences capable of hybridizing, under stringent conditions, to at least a portion of D. immitis nucleic acid sequence p4 and/or to at least a portion of D. immitis nucleic acid sequence p22U; to isolated parasitic helminth proteins that are encoded by such parasitic helminth nucleic acid sequences and that are capable of selectively binding to at least one component of immune serum capable of inhibiting helminth development; and to antibodies raised against such isolated parasitic helminth proteins. The present invention also relates to therapeutic compositions comprising such isolated nucleic acid sequences, proteins and/or antibodies. The present invention also includes methods to produce and use such nucleic acids, proteins, antibodies and therapeutic compositions capable of protecting animals from parasitic helminth infection and, particularly, from heartworm infection.
Inventors:
Greve, Robert Bee.
Frank, Glenn Earl.
Micah Greave, Masha
Trip, Cynthia Ann
Frank, Glenn Earl.
Micah Greave, Masha
Trip, Cynthia Ann
Application Number:
JP51638094A
Publication Date:
June 25, 1996
Filing Date:
January 12, 1994
Export Citation:
Assignee:
Parabacs, Inc.
Colorado State University Research Foundation
Colorado State University Research Foundation
International Classes:
C12N15/09; A61K31/70; A61K35/12; A61K35/68; A61K38/00; A61K38/08; A61K38/17; A61K39/00; A61K39/395; A61P33/00; C07H21/04; C07K14/435; C07K16/18; C12N5/00; C12N5/10; C12N9/64; C12N15/12; C12N15/63; C12P21/02; C12P21/04; C12P21/08; G01N33/50; G01N33/53; G01N33/569; C12R1/91; (IPC1-7): C12N15/09; A61K31/70; A61K35/12; A61K35/68; A61K38/00; A61K39/00; A61K39/395; C07H21/04; C12N5/10; C12P21/02
Attorney, Agent or Firm:
Hironobu Onda