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Title:
NEW PEPTIDE AND ENTEROKINESIS INHIBITOR CONTAINING THE SAME
Document Type and Number:
Japanese Patent JP2002293799
Kind Code:
A
Abstract:

To obtain an enterokinesis inhibitor which has an inhibitory action on peristalsis of the stomach, does not cause a clinical adverse effect with high safety, is effective for treatment before digestive tract examination, gastrointestinal X-ray examination, abdominal MRI examination, endoscopy, etc., can be provided as a solution, thus simply used and is economic.

This peptide comprises and amino acid sequence from N terminal to at least 23rd amino acid sequence of an amino acid sequence represented by formula (I) His-Xal-Asp-Xa2-Xa3-Phe-Thr-Xa4-Xa5-Xa6-Xa7-Leu-Leu-Xa8-Xa9- Leu-Xa10-Xa11-Xa12-Lys-Tyr-Leu-Xa13-Ser-Xa14-Xa15-Gly-Ser-Xa16-Thr-Ser-Pro- Xa17-Pro-Pro-Ser-Ser (I) (Xa1 to Xa17 can take 2 or 3 specific amino acids, respectively) and has an inhibitory action of enterokinesis. This enterokinesis inhibitor comprises the peptide or its pharmacologically acceptable salt as an active ingredient.


Inventors:
KASHIMOTO KAZUHISA
MATSUMOTO ASAMI
Application Number:
JP2001097191A
Publication Date:
October 09, 2002
Filing Date:
March 29, 2001
Export Citation:
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Assignee:
ITOHAM FOODS INC
International Classes:
A61K38/00; A61P43/00; C07K14/605; (IPC1-7): C07K14/605; A61K38/00; A61P43/00
Domestic Patent References:
JPH0692991A1994-04-05
JPH0390034A1991-04-16
Foreign References:
WO1991006565A11991-05-16
WO2000066138A22000-11-09
WO2000077039A22000-12-21
WO2000066142A22000-11-09
WO2000005260A12000-02-03
Attorney, Agent or Firm:
Yusuke Hiraki (1 person outside)