Title:
新規フェニルアラニン誘導体
Document Type and Number:
Japanese Patent JP4452899
Kind Code:
B2
Abstract:
Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to alpha 4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning alpha 4 integrin in which alpha 4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sj¦gren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection. wherein R1 is a methyl group and R2 is a methoxy group.
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Inventors:
Tatsuya Okuzumi
Kazuyuki Sagi
Toshihiko Yoshimura
Yuji Tanaka
Eiji Nakanishi
Miho Ono
Murata Masahiro
Kazuyuki Sagi
Toshihiko Yoshimura
Yuji Tanaka
Eiji Nakanishi
Miho Ono
Murata Masahiro
Application Number:
JP2003554643A
Publication Date:
April 21, 2010
Filing Date:
December 13, 2002
Export Citation:
Assignee:
AJINOMOTO CO.,LTD.
International Classes:
C07D209/48; A61K31/403; A61K31/4035; A61K31/437; A61K31/4375; A61K31/47; A61K31/4704; A61K31/4709; A61K31/472; A61K31/502; A61K31/517; A61P1/00; A61P1/04; A61P3/10; A61P9/00; A61P9/10; A61P11/06; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P35/00; A61P35/04; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D215/22; C07D215/227; C07D215/36; C07D215/38; C07D217/24; C07D237/32; C07D239/36; C07D239/96; C07D401/12; C07D403/12; C07D471/04
Domestic Patent References:
| JP3440469B2 | ||||
| JP2002028830A |
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama