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Title:
NEW PHYSIOLOGICAL ACTIVE SUBSTANCE BEQUIONSTAIN A AND B, ITS PRODUCTION AND ITS USE
Document Type and Number:
Japanese Patent JPH05271145
Kind Code:
A
Abstract:

PURPOSE: To obtain new physiological active substance bequionstain A and B having high specificity, inhibitory activity against glutathione transferase and immunomodulating action and its pharmaceutically acceptable salt.

CONSTITUTION: A physiological active substance bequionstain A and B of formula I (R is COOH and H, respectively or its pharmaceutically acceptable salt such as bequionstain A of formula II and bequionstain B of formula III. The compound of formula I is obtained by culturing a bacterium (FERM P-1,384-OF12) in a nutritive medium and collecting from the culture mixture. A glutathione transferase inhibitor is obtained from bequionstain A or its pharmaceutically acceptable salt and a medical additive. An immunomodulator is obtained from bequionstain A or B or its pharmaceutically acceptable salt and a medical additive.


Inventors:
Takeuchi, Tomio
Aoyanagi, Takaaki
Osanawa, Hiroshi
Hamada, Masa
Muraoka, Yasuhiko
Aoyama, Takayuki
Application Number:
JP1991000307610
Publication Date:
October 19, 1993
Filing Date:
November 22, 1991
Export Citation:
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Assignee:
MICROBIAL CHEM RES FOUND
International Classes:
A61K31/12; A61P37/00; A61P43/00; C07C50/36; C07C66/00; C12N9/99; C12P15/00; C12R1/465; (IPC1-7): C07C50/36; A61K31/12; C07C66/00; C12P15/00
Attorney, Agent or Firm:
浅村 皓 (外3名)