Title:
NEW PIPERIDINE DERIVATIVES
Document Type and Number:
Japanese Patent JP2004285072
Kind Code:
A
Abstract:
To provide a compound useful for producing piperidine derivatives useful for an antihistamine agent, an antiallergic agent or a bronchodilator.
The piperidine formyl phenyl alcohol compound or piperidine formyl phenyl ketone compound is expressed by a specific general formula. A specific piperidine hydroxyethyl phenyl ketone derivative is obtained in the following process, a step preparing phenethyl alcohol by reacting a specific benzeneacetic acid compound with a proper reducing agent, producing a ω-hydroxyethyl phenyl ketone by reacting a ω-halo compound with the phenetyl alcohol in the presence of a proper Lewis acid and then reacting with a specific piperidine compound in the presence of a proper non-nucleophilic reagent.
Inventors:
King, Chi-hsin
Kaminski, Michele A.
Kaminski, Michele A.
Application Number:
JP2004000137675
Publication Date:
October 14, 2004
Filing Date:
May 06, 2004
Export Citation:
Assignee:
MERRELL PHARMACEUTICALS INC
International Classes:
C07D211/14; C07D211/22; C07D211/70; (IPC1-7): C07D211/22
