新規なポリシクロキサントン及びそれらの使用

Japanese Patent JP2004501924

A

A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus Actinomadura sp.), of a compound designated IB-00208. The class of the formulae (I) or (II) where R<1 >can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R<2 >and R<3 >can be hydrogen, alkyl, or together R<2 >and R<3 >form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.

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Perez-Bus, Julia
Cannade, Librada Maria
Garcia Gravaros, Dolores
Romero, Francisco
Fernando, Espriego

JP2002505787A

January 22, 2004

June 29, 2001

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Institut Biomar Sociedad Anonima

A61K31/366; A61P31/04; A61P35/00; C07D493/04; C07H17/08; C12N1/20; C12P17/18; C12P19/60; C12R1/03; (IPC1-7): C07D493/04; A61K31/366; A61P35/00; C12N1/20; C12P17/18; C12P19/60

Takehiko Suzue
Sadao Muramatsu
Ryo Hashimoto
Toshio Shirane

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