PURPOSE: To isolate and establish human senescence-related protein H-SMP 30 and further establish its binding protein and to provide an immunological measurement method for which it is utilized, a DNA coding H-SMP 30 and a method for detection of the DNA.

CONSTITUTION: This polypeptide has a specific amino acid sequence. The reagent for measuring human senescence marker protein SMP 30 contains a cloned DNA containing the DNA region coding this polypeptide, an antibody against this polypeptide or its part as an antigen or a fragment affinitive to the antigen. A probe for detecting a gene coding human senescence-related marker protein SMP 30, containing a single-stranded nucleic acid fragment containing a part of a base sequence represented by another sequence or its complementray base sequence.