Title:
NEW PROCESS FOR PRODUCING LACTONE DERIVATIVE
Document Type and Number:
Japanese Patent JP3135658
Kind Code:
B2
Abstract:
PURPOSE: To produce a lactone derivative, e.g. a macrolide antibiotic substance such as erythromycin, from a hydroxycarboxylic acid derivative under milder condition in high efficiency.
CONSTITUTION: A hydroxycarboxylic acid derivative of formula I (A is alkylene which may have substituent and/or unsaturated bond; Z is H or SiR1R2R3; R1 to R3 are lower alkyl) is made to react with a carboxylic acid anhydride of formula II [R4 is (substituted) aryl, preferably 4-fluorophenyl or 4- trifluoromethylphenyl] in the presence of a catalytic amount (preferably 0.01-100mol% based on the compound of formula I) of a cationic catalyst, preferably various Lewis acids (e.g. titanium tetrachloride, hafnium chloride and zirconium chloride), a complex salt of a silver salt (e.g. silver perchltrate and silver trifluoromethanesulfonate) and various Lewis acids, tin(II) trifluoromethanesulfonate, etc., at 0-50°C (preferably 10-30°C) to obtain the corresponding lactone derivative in high yield.
Inventors:
Mitsuaki Mukaiyama
Isamu Shiina
Miyashita Misasa
Isamu Shiina
Miyashita Misasa
Application Number:
JP2399992A
Publication Date:
February 19, 2001
Filing Date:
February 10, 1992
Export Citation:
Assignee:
Kyorin Pharmaceutical Co., Ltd.
International Classes:
B01J27/10; B01J31/12; C07B61/00; C07D307/32; C07D307/33; C07D309/30; C07D313/04; (IPC1-7): C07D307/33; B01J27/10; B01J31/12; C07D309/30; C07D313/04
Attorney, Agent or Firm:
Masayuki Kishida (2 outside)