Title:
腫瘍および炎症性疾患治療用の新規プロドラッグ
Document Type and Number:
Japanese Patent JP4392065
Kind Code:
B2
Abstract:
Glycosyl derivatives of formula Glycosyl-YÄ-C(=Y)-X-Üp-W(R)n-Z-C(=Y)-active agent (I) and their salts are new: glycosyl = enzymatically cleavable poly-, oligo- or mono-saccharide; W = 5-14 membered aryl, naphthyl, indenyl, anthryl, phenanthryl, 5-14 membered heterocyclyl (containing 1-4 O, N or S), 1-6C alkyl, 2-6C alkenyl, 3-6C cycloalkyl or phenyl; R = H, 1-4C alkyl, phenyl, methoxy, carboxy, methyloxycarbonyl, CN, OH, NO2, F, Cl, Br, sulphonyl, sulphonamide or 1-4C sulphonalkylamide; p = 0-1; n = 0-3; X = O, NH, methyleneoxy, methyleneamino, methylene-1-4C alkylamino, 1-4C alkylamino, 3-6C cycloalkylamino; Y = O or NH; Z = 1-4C alkylamino, NCH3, C(CH3)2NH, CH(CH3)NH, C(CH3)2N(R<2>) or NH if W = 1-6C alkyl; R<2> = 1-4C alkyl; and active agent = a compound with biological effect bonded via an oxygen, primary or secondary amine or an imino group.
Inventors:
Klaus Boslet
Jerck Chietsk
Manfred Gelken
Liner Shoutrop
Claude Monelle
Jiyan-Claude Florent
Frederik Schmitt
Jerck Chietsk
Manfred Gelken
Liner Shoutrop
Claude Monelle
Jiyan-Claude Florent
Frederik Schmitt
Application Number:
JP5598397A
Publication Date:
December 24, 2009
Filing Date:
March 11, 1997
Export Citation:
Assignee:
Sanofi-Aventis Deutschland Gesellschaft Mitt Beschlenktel Haftung
International Classes:
A61K31/706; A61K31/70; C07H15/203; A61K31/7012; A61K31/7028; A61K31/7034; A61K47/48; A61P29/00; A61P35/00; A61P37/00; A61P43/00; C07H15/26
Domestic Patent References:
| JP6293665A | ||||
| JP7149667A | ||||
| JP6506687A |
Foreign References:
| CA2081281A1 |
Other References:
犬塚 貞明ら,日本ハイパーサーミア誌,10(1),pp.42-48 (1994)
杉森 宏ら,癌と化学療法,20(2),pp.287-290 (1993)
BLAKEY, D.C., et al.,Br. J. Cancer,72(5),pp.1083-1088 (1995)
杉森 宏ら,癌と化学療法,20(2),pp.287-290 (1993)
BLAKEY, D.C., et al.,Br. J. Cancer,72(5),pp.1083-1088 (1995)
Attorney, Agent or Firm:
Junji Yuda
Shoji Miwa
Yoshihisa Ishii
Chika Takagi
Shoji Miwa
Yoshihisa Ishii
Chika Takagi