To provide a method for efficiently producing carbapenem antibiotic in a short time which solves the problems that (1) a column chromatography must be applied and that (2) insoluble salts are required to be taken out once.
Characteristically, a compound represented by general formula I is reacted with a compound represented by X-H (general formula II) (wherein, X is a substituent selected from the group consisting of formulas X-1 to X-8) to give a compound represented by general formula III or a salt thereof. Then, a protective group R3 is deprotected to give a compound represented by general formula IV or a salt thereof, and the compound represented by general formula IV or a salt thereof is purified by crystallization to give a purified compound represented by general formula IV, its salt or hydrate. The above purpose is achieved by this production method.
| WO1999064049 | NOVEL ANTIBACTERIAL AGENTS |
| JPS5414594 | PREPARATION OF BETA-LACTAMASE INHIBITING SUBSTANCE |
| JP2011057602 | METHOD FOR REMOVING REMAINING PALLADIUM |
ISHIZUKA HIROYUKI
KOIWA ATSUSHI
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