Title:
NEW PROSTAGLANDIN DERIVATIVE
Document Type and Number:
Japanese Patent JP3195002
Kind Code:
B2
Abstract:
PURPOSE: To provide the subject new compound having strong platelet- coagulating action and antianginal action and low toxicity, and useful as a preventive and treating agent for circulatory diseases.
CONSTITUTION: A prostaglandin I2 compound having a halogen atom on 7-site C atom of natural-type prostaglandin I2 and a cycloalkylene group on the α-chain, its ester and its salt expressed by formula I [R1 is (substituted) 1-10C alkyl, (substituted) 5- or 6-membered cycloalkyl, etc. ; R2 is H, 1-10C alkyl or cation; one of R3 and R4 is H and the other is F or Cl; (k), (l), (m) and (n) are 0-6; 0≤k+n≤4; 1≤l+m≤6], etc., e.g. 2,3-methylene-7α-fluoro-17,20- dimethyl PGI2. The compound of formula I can be produced by converting a compound of formula II (R21 is 1-10C alkyl, etc.; R31 and R41 are protecting group other than trimethylsilyl) into the compound of formula III and subjecting the product to fluorination, deprotection and, as necessary, hydrolysis, salt- forming, etc.
Inventors:
Tomoyuki Asai
Yoshitomi Morisawa
Arata Yasuda
Taku Yamamoto
Takekazu Fujitani
Kazu Hosoki
Yoshitomi Morisawa
Arata Yasuda
Taku Yamamoto
Takekazu Fujitani
Kazu Hosoki
Application Number:
JP25455791A
Publication Date:
August 06, 2001
Filing Date:
September 06, 1991
Export Citation:
Assignee:
Asahi Glass Co., Ltd.
International Classes:
A61K31/557; A61K31/5575; A61P7/02; A61P9/00; A61P9/08; A61P9/10; C07D307/935; (IPC1-7): C07D307/935; A61K31/5575; A61P7/02; A61P9/10