Title:
NEW PYRAZOLE-3-CARBOXYAMIDE DERIVATIVES, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS IN WHICH THEY ARE PRESENT
Document Type and Number:
Japanese Patent JP3825062
Kind Code:
B2
Abstract:
PURPOSE: To obtain the subject new compound having high affinity with cannabinoid receptor and useful as a psychopharmaceutical especially for treating thymic diseases, anxiety, thymopathy, vomit, dysmnesia and the like.
CONSTITUTION: A compound of formula I [g2-g6, w2-w6 are each independently H, Cl, Br, I, a 1-3C alkyl, a 1-3C alkyl, a 1-3C alkoxy or the like; R1 is a 1-6C alkyl, H; R2 is +NR3R5R6, NR5R6 (R3 is a 1-6C alkyl or the like; R5 is H, a 1-5C alkyl], its salt, and their solvate compounds. For example, N-(1,2,3,6- tetrahydrophenyl)-4-methylpyrazole-3-carboxamide hydrochloride. The compound of formula I is obtained e.g. by treating the functional derivative of a pyrazole-3- carboxylic acid of formula II with an amine of the formula: HNR1R2.
Inventors:
Francis bals
Pierre Casera
Christian Congui
Serge Martine
Muriel Rinaldi
Pierre Casera
Christian Congui
Serge Martine
Muriel Rinaldi
Application Number:
JP31522494A
Publication Date:
September 20, 2006
Filing Date:
December 19, 1994
Export Citation:
Assignee:
Sanofi-Aventis
International Classes:
C07D231/14; A61K31/415; A61K31/435; A61K31/4427; A61K31/445; A61K31/55; A61P25/00; A61P25/14; A61P25/18; A61P43/00; C07D401/12; C07D403/12; C07D453/02; C07D471/08; (IPC1-7): C07D231/14; A61K31/415; A61K31/435; A61K31/445; A61K31/55; C07D401/12; C07D471/08
Domestic Patent References:
| JP3137222B2 | ||||
| JP2001026541A | ||||
| JP6073014A | ||||
| JP4244065A |
Other References:
MUSTAFA, A., et al.,Can. J. Chem.,41(7),pp.1813-1818 (1963)
KHATTAB, S.A., et al.,J. Chem. Eng. Data,22(1),pp.104-110 (1977)
RINALDI-CARMONA, M., et al.,FEBS Lett.,350,pp.240-244 (1994)
KHATTAB, S.A., et al.,J. Chem. Eng. Data,22(1),pp.104-110 (1977)
RINALDI-CARMONA, M., et al.,FEBS Lett.,350,pp.240-244 (1994)
Attorney, Agent or Firm:
Takehiko Suzue