Title:
新しいピラゾロ[4,3-d]ピリミジン、その調整方法、及び治療方法
Document Type and Number:
Japanese Patent JP2005527565
Kind Code:
A
Abstract:
The invention relates to 3-, 5-, 7-trisubstituted pyrazoloÄ4,3-dÜpyrimidines represented by the general formula I and pharmaceutically acceptable salts thereof, wherein R3 is an optionally substituted alkyl, cycloalkyl, cycloheteroalkyl, cycloalkyl alkyl, aryl or alkylaryl group; R5 is halogen, -NHNH2, -NHOH, NHCONH2, guanylo (NH-C(NH)NH2) an optionally substituted C1-C6 alkyl, alkenyl, alkinyl, C3-C15 cycloalkyl, Rf (C3-C15 cycloalkyl), heterocycle, heteroalkyl, aryl, heteroaryl, arylalkyl, cycloheteroalkyl, cycloheteroalkyl alkyl, heteroarylalkyl group, the group -C(O)-Ra, -C(O)NRbRc, -SO3Rd, or -NHC(O)Re, wherein Ra and Rf are an optionally substituted C1-C6 alkyl, alkenyl, or alkinyl group, Rb, Rc and Rd are independently selected from the group consisting of H, optionally substituted C1-C6 alkyl, alkenyl, or alkinyl group, and Re is a hydroxy, amino, alkoxy, alkylamino, optionally substituted C1-C6 alkyl, alkenyl or alkinyl group; or the group -X-R5', wherein X is -NH-, -O-, -S- or -N(alkyl)- and R5' is hydrogen, an optionally substituted C1-C6 alkyl, alkenyl, alkinyl, C3-C15 cycloalkyl, , Rf(C3-C15 cycloalkyl), aryl, heterocycle, hetero C1-C6 alkyl, arylalkyl, heteroaryl, cycloheteroalkyl, cycloheteroalkyl alkyl, or heteroarylalkyl group, the group -C(O)-Ra, -C(O)NRbRc, -SO3Rd, or -NHC(O)Re, wherein Ra, Rb, Rc, Rd, Re and Rf have the above meaning, and R7 is halogen, -NHNH2, NHOH, NHCONH2, guanylo (NH-C(NH)NH2) or the group -X-R7', wherein X has the above meaning and the meaning of R7' is as defined for R5'.
Inventors:
Marafcopha Daniela
Hafrikke reball
Christoph Bradymir
Renobel Rene
Starnad Miroslav
Hafrikke reball
Christoph Bradymir
Renobel Rene
Starnad Miroslav
Application Number:
JP2003580337A
Publication Date:
September 15, 2005
Filing Date:
March 27, 2003
Export Citation:
Assignee:
Ustaf Experimentalni Botaniki Abu Shir (Institute of Experimental Botany Academy of Sciences of the Czech Republic)
International Classes:
A61K31/136; A61K31/337; A61K31/519; A61K31/704; A61K33/24; A61P3/10; A61P9/00; A61P9/08; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/12; A61P33/00; A61P35/00; A61P37/02; A61P43/00; C07D487/04; (IPC1-7): C07D487/04; A61K31/136; A61K31/337; A61K31/519; A61K31/704; A61K33/24; A61P3/10; A61P9/00; A61P9/08; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/06; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/12; A61P33/00; A61P35/00; A61P37/02; A61P43/00
Domestic Patent References:
| JPH09188682A | 1997-07-22 | |||
| JP2001519437A | 2001-10-23 | |||
| JPH0641133A | 1994-02-15 | |||
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Foreign References:
| WO1998008847A1 | 1998-03-05 | |||
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| WO2001019827A1 | 2001-03-22 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi