Title:
新規sEH阻害剤およびそれらの使用
Document Type and Number:
Japanese Patent JP5411867
Kind Code:
B2
Abstract:
The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R3, R5a, R6a A, B, Y, x, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Inventors:
Yun Din
Reamer Kay Sarji
Joseph Paul Marino Jr.
Reamer Kay Sarji
Joseph Paul Marino Jr.
Application Number:
JP2010529085A
Publication Date:
February 12, 2014
Filing Date:
October 10, 2008
Export Citation:
Assignee:
GlaxoSmithKline LLC
International Classes:
C07D401/04; A61K31/53; A61K31/55; A61P1/16; A61P3/04; A61P3/10; A61P9/00; A61P9/04; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P13/12; A61P43/00; C07D401/14; C07D409/14
Domestic Patent References:
| JP8501573A | ||||
| JP2007126454A |
Foreign References:
| US20070225283 | ||||
| WO2007106705A1 | ||||
| WO2007098352A1 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Mitsutaka Iwasaki
Michiko Matsutani
Nishino Mitsuru
Sakurai Yoko
Satoshi Hashimoto
Yasushi Ochiai
Mizuhara Masahiro
Hiroshi Yamazaki
Mitsutaka Iwasaki
Michiko Matsutani
Nishino Mitsuru
Sakurai Yoko
Satoshi Hashimoto
Yasushi Ochiai
Mizuhara Masahiro