Title:
新規自己集合分子
Document Type and Number:
Japanese Patent JP4471656
Kind Code:
B2
Abstract:
There is provided a method of forming a multimeric complex having affinity for a target. The method comprises: obtaining a plurality of self-assembly molecules, said self-assembly molecules including complementary self-assembly units such as verotoxin subunit B, each of which is operatively connected to an interaction domain such as a single domain antibody specific for the target; and combining said self-assembly molecules such that at least three said self-assembly units simultaneously bind to one another so as to permit the single domain antibodies to bind the target.
Inventors:
Mackenzie, C., Roger
Tsang, Jambin
Tsang, Jambin
Application Number:
JP2003547949A
Publication Date:
June 02, 2010
Filing Date:
November 29, 2002
Export Citation:
Assignee:
NATIONAL RESEARCH COUNCIL OF CANADA
International Classes:
G01N33/566; A61K38/00; A61K39/395; A61P31/12; A61P35/00; A61P43/00; C07K14/235; C07K14/245; C07K16/00; C07K16/26; C07K19/00; G01N33/569; G01N33/574
Foreign References:
| WO2001049866A1 | ||||
| WO2001027144A1 |
Other References:
Linda M. Facchini, et al.,A Verotoxin 1 B Subunit-Lambda CRO Chimeric Protein Specifically Binds Both DNA and Globotriaosylcermide(Gb3) to Effect Nuclear Targeting of Exogenous DNA in Gb3 Positive Cells.,Experimental Cell Research,2001年 9月10日,Vol.269, No.1,p.117-129
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Ishii Teiji
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka