Title:
NEW STABLE CRYSTALLINE FORM OF CEPHALOSPORIN INTERMEDIATE PRODUCT
Document Type and Number:
Japanese Patent JP2572563
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a new crystalline form (β-form) easily separable and good in stability and useful for a non-oral antibiotic drug having a high antibacterial activity by crystallizing a specific cephalosporin from an aqueous solution in a specific pH range.
SOLUTION: This crystalline form (β-form) is obtained by crystallizing (6R,7 R)-7-[[2-(2-amino-4-thiazolyl)-(Z)-2-(1-tert. butoxycarbonyl-1-methyl-ethoxy) imino]acetamido]-3-(1-pyridiniummethyl)-3-cephem-4-carboxylate (ceftazidime-t- butyl ester) shown by the formula from an aqueous solution in a pH range of 3.5 to 7.5 and the wave length α (&angst ) of its X-ray spectrum (the intensity I shown by (w): weak, (m): medium, and (d): diffusion) is 22.0(m), 10.0(w), 8.5(m), 7.3(w), 6.7(m), 5.9(md), 5.6(m), 5.3(wd), 4.2(w), 3.94(w), 3.82(w), 3.7(w) and 3.3(w).
Inventors:
BERUNHARUTO KURISUCHAN PURAAGERU
KAARU BEZERII
BERUNAA BAITO
KAARU BEZERII
BERUNAA BAITO
Application Number:
JP563996A
Publication Date:
January 16, 1997
Filing Date:
January 17, 1996
Export Citation:
Assignee:
BIOCHEMIE GMBH
International Classes:
C07D501/00; C07B63/00; C07D501/04; C07D501/12; C07D501/46; (IPC1-7): C07D501/46
Domestic Patent References:
| JP62108883A | ||||
| JP61501780A |
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)