NEW SUBSTITUTED DIMER COMPOUND, METHOD FOR PRODUCING THE SAME AND MEDICINAL COMPOSITION CONTAINING THE SAME

Title:

NEW SUBSTITUTED DIMER COMPOUND, METHOD FOR PRODUCING THE SAME AND MEDICINAL COMPOSITION CONTAINING THE SAME

Document Type and Number:

Japanese Patent JP3688549

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To obtain a new compound which exhibits highly strong affinity with melatonin receptors and/or exhibits good selectivity for any one melatonin- agonizing receptor sub-type.
SOLUTION: A compound of the formula : A-G1-Cy-G2-Cy-G3-B {A is a group of formula I [Q is S or the like; R1 to R3 are each Ra [Ra is a (substituted) 1 to 6C alkyl or the like] or the like]; B is a group of formula II; G1 and G3 are each a (substituted) 1 to 4C alkylene chain; Cy is a group of formula III (X, Y are each OH or the like; R4 is H or the like; the broken line is a single bond or the like) or the like; G2 is a chain of formula IV [W1 to W3 are each 0 or the like; 0≤(n); (m)≤6], provided that N-{2-[5-({3-[2(acetylamino)ethyl]-1H- indol-5-yl}-methyl)-1H-indol-3-yl]-ethyl}acetamide is excluded}, for example, N-(2-{7-({8-[2-(acetylamino)ethyl]-2-naphthyl]oxy)ethoxy}-1-naphthyl)ethyl) acetamide. The compound of the formula: A-G1-Cy-G2-Cy-G3-B is obtained, for example, by a method using a compound the formula: A-G1-Cy-OMe as a starting substance.

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Inventors:

Daniel Lesur
Sed Yoo
Carol Dessan-Francois
Francois Lefron
Gerard Guillaume
Marie-Claude Vio
Carolyn Benjan
Philippe De Lagrange
Pierre Renard

Application Number:

JP2000081290A

Publication Date:

August 31, 2005

Filing Date:

March 23, 2000

Export Citation:

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Assignee:

Réra Bora Toir Servier

International Classes:

A61K31/16; A61K31/165; A61K31/33; A61K31/341; A61K31/343; A61K31/381; A61K31/403; A61K31/404; A61K31/4045; A61K31/437; A61P3/04; A61P3/10; A61P5/00; A61P9/00; A61P15/18; A61P25/04; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P35/00; A61P37/02; A61P43/00; B01J31/24; C07B61/00; C07C231/12; C07C233/18; C07C233/20; C07C233/36; C07C233/60; C07C233/73; C07C235/34; C07C271/16; C07C275/24; C07C319/14; C07C323/42; C07D209/14; C07D209/16; C07D339/08; C07D307/68; C07D307/79; C07D307/81; C07D311/58; C07D319/20; C07D333/58; C07D471/04; C07D519/00; (IPC1-7): C07C233/18; C07C233/20; C07C233/36; C07C233/60; C07C233/73; C07C235/34; C07C271/16; C07C275/24; C07C319/14; C07C323/42; C07D209/16; C07D307/68; C07D307/79; C07D307/81; C07D311/58; C07D319/20; C07D333/58; C07D471/04

Domestic Patent References:

JP2002510290A
JP11510804A
JP8325217A

Attorney, Agent or Firm:

Hajime Tsukuni
Fumio Shinoda

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