Title:
新規な糖連結クロリン誘導体
Document Type and Number:
Japanese Patent JP5290142
Kind Code:
B2
Abstract:
Disclosed is a novel glycoconjugated chlorin derivative which is useful as a substance for photodynamic therapy, is stable, and can act a photosensitizer having high phototoxicity even when used in a small quantity. Also disclosed is a method of producing the derivative. Specifically disclosed are a S-glycosylated chlorin derivative represented by the following general formula (1) and a metal complex thereof. In the general formula (1), X 1 to X 20 independently represent a group selected from the group consisting of F-, sugar-S-, sugar-Z-Sand sugar-O-Z-S- and at least one among X 1 to X 20 represents a group selected from the group consisting of sugar-S-, sugar-Z-S- and sugar-O-Z-S- (wherein F represents a fluorine atom, Z represents an oxygen atom, Z represents a hydrocarbon group having 1 to 6 carbon atoms); and R 5 and R 6 independently represent a hydrogen atom or an organic group or may together form a ring.
Inventors:
Makoto Obata
Shigenobu Yano
Hirohara Shiho
Shigenobu Yano
Hirohara Shiho
Application Number:
JP2009500148A
Publication Date:
September 18, 2013
Filing Date:
February 12, 2008
Export Citation:
Assignee:
San-Ei Gen F.F.I.,Inc.
International Classes:
C07H15/26; A61K31/7056; A61P35/00; A61P43/00
Domestic Patent References:
| JP2005507383A | 2005-03-17 | |||
| JP2002523509A | 2002-07-30 | |||
| JP2005500335A | 2005-01-06 | |||
| JP2000007693A | 2000-01-11 | |||
| JP2005507383A | 2005-03-17 | |||
| JP2002523509A | 2002-07-30 | |||
| JP2005500335A | 2005-01-06 |
Foreign References:
| WO2006088476A2 | 2006-08-24 | |||
| WO2000061585A2 | 2000-10-19 |
Other References:
JPN6013008459; ＨＩＲＯＨＡＲＡ，Ｓ． ｅｔ ａｌ: 'Ｓｕｇａｒ-ｄｅｐｅｎｄｅｎｔ ａｇｇｒｅｇａｔｉｏｎ ｏｆ ｇｌｙｃｏｃｏｎｊｕｇａｔｅｄ ｃｈｌｏｒｉｎｓ ａｎｄ ｉｔｓ ｅｆｆｅｃｔ ｏｎ ｐｈｏｔｏｃｙｔｏｔｏｘｉｃｉｔｙ ｉｎ ＨｅＬａ' Ｊｏｕｒｎａｌ ｏｆ Ｐｈｏｔｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｐｈｏｔｏｂｉｏｌｏｇｙ， Ｂ： Ｂｉｏｌｏｇｙ Ｖｏｌ．８４， Ｎｏ．１, 2006, ｐｐ．５６-６３
JPN6013008461; ＣＨＥＮ，Ｘ． ｅｔ ａｌ: 'Ｅｆｆｉｃｉｅｎｔ Ｓｙｎｔｈｅｓｉｓ ａｎｄ Ｐｈｏｔｏｄｙｎａｍｉｃ Ａｃｔｉｖｉｔｙ ｏｆ Ｐｏｒｐｈｙｒｉｎ-Ｓａｃｃｈａｒｉｄｅ Ｃｏｎｊｕｇａｔｅｓ： Ｔａｒｇｅｔｉｎｇ ａｎｄ Ｉｎｃａ' Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４３， Ｎｏ．３４, 2004, ｐｐ．１０９１８-１０９２９
JPN6013008465; 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ ｔｈｉｏｇｌｙｃｏｓｙｌａｔｅｄ ｐｏｒｐｈｙｒｉｎｓ ｆｏｒ ａｎ ａｐｐｌｉｃａｔｉｏｎ ｉｎ ｐｈｏｔｏｄｙｎａｍｉ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１０， Ｎｏ．１, 2001, ｐｐ．５７-６９
JPN6013008461; ＣＨＥＮ，Ｘ． ｅｔ ａｌ: 'Ｅｆｆｉｃｉｅｎｔ Ｓｙｎｔｈｅｓｉｓ ａｎｄ Ｐｈｏｔｏｄｙｎａｍｉｃ Ａｃｔｉｖｉｔｙ ｏｆ Ｐｏｒｐｈｙｒｉｎ-Ｓａｃｃｈａｒｉｄｅ Ｃｏｎｊｕｇａｔｅｓ： Ｔａｒｇｅｔｉｎｇ ａｎｄ Ｉｎｃａ' Ｂｉｏｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４３， Ｎｏ．３４, 2004, ｐｐ．１０９１８-１０９２９
JPN6013008465; 'Ｓｙｎｔｈｅｓｉｓ ａｎｄ ｂｉｏｌｏｇｉｃａｌ ｅｖａｌｕａｔｉｏｎ ｏｆ ｔｈｉｏｇｌｙｃｏｓｙｌａｔｅｄ ｐｏｒｐｈｙｒｉｎｓ ｆｏｒ ａｎ ａｐｐｌｉｃａｔｉｏｎ ｉｎ ｐｈｏｔｏｄｙｎａｍｉ' Ｂｉｏｏｒｇａｎｉｃ ＆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．１０， Ｎｏ．１, 2001, ｐｐ．５７-６９
Attorney, Agent or Firm:
Eriko Kamiya