To obtain a new subject sugar derivative expressing strong selectin dependent anti-inflammatory action, excellent in stability and safety and useful as an anti-inflammatory agent, etc., and obtained by condensing a sugar having an eliminable group with an alcohol and succeedingly sulfating or phosphating after the condensation.
This new sulfated or phosphated sugar derivative (or its salt) is expressed by formula I [R1 is H, a sulfuric acid ester, a phosphoric acid ester or L-fucose; R2 to R4 are each H, a sulfuric acid ester or a phosphoric acid ester; (l) is 0 or 1; (m) is 0-15 integer; (n) is 0-21 integer]. (e.g. 2- methylpropyl-D-garactopyranoside 3-sulfate, etc.), exhibits strong selectin- dependent anti-inflammatory action, is excellent in safety and preservation stability and useful for curing and preventing ARDS, sepsis, rheumatism, shock and nephritis. The compound is obtained by reacting a sugar of formula II (X is an eliminable group; Ac is acetyl) with a compound of formula III, then eliminating protecting groups and sulfating or phosphating hydroxyl groups.
IGAMI KOSEI
KAKIUE TAKUJI
HAMASHIMA HITOSHI
SHIROMORI TAKAHITO
TASHIMO SATOSHI
ISHIWATARI YOSHIRO
YOKOCHI SHOJI
MITANI TAKAHIKO
SUZUKI YASUO
HASEGAWA AKIRA
