Title:
新規スルフォンアミドウレア化合物
Document Type and Number:
Japanese Patent JP2021534148
Kind Code:
A
Abstract:
本発明は、式(I):【化1】の化合物に関し、式中、QはOまたはSから選択され、R1およびR3は、それぞれ独立に水素または任意に置換されてよいヒドロカルビル基であるか、またはR1およびR3は、それらが結合される窒素原子と一緒に、3〜12員の任意に置換されてよい環式基を形成してよく、R2は、α位で置換された環式基であり、R2は、さらに任意に置換されてよい。本発明はさらに、このような化合物の塩、溶媒和物およびプロドラッグに、このような化合物を含む医薬組成物に、および医学的障害および疾患の、特にNLRP3阻害による、治療および予防におけるこのような化合物の使用に、関する。【選択図】なし
Inventors:
Cooper, matthew
Mirror, david
Mactle, Angus
Shannon, Jonathan
Carrillo Allegi, Hawkin
Van Wiltenburg, Jimmy
Van Helpt, Yochem Theodore
Mirror, david
Mactle, Angus
Shannon, Jonathan
Carrillo Allegi, Hawkin
Van Wiltenburg, Jimmy
Van Helpt, Yochem Theodore
Application Number:
JP2021507616A
Publication Date:
December 09, 2021
Filing Date:
August 12, 2019
Export Citation:
Assignee:
Inflation Isome Limited
International Classes:
C07C307/06; A61K31/397; A61K31/64; A61P1/16; A61P3/00; A61P9/00; A61P11/00; A61P13/12; A61P25/00; A61P25/18; A61P27/02; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P43/00; C07D205/04; C07D207/09; C07D207/14; C07D207/48; C07D209/34; C07D211/56; C07D211/96; C07D229/02; C07D243/08; C07D401/12; C07D403/12; C07D471/04; C07D487/04; C07D487/08; C07D487/10
Domestic Patent References:
JPH06501707A | 1994-02-24 | |||
JP2003104878A | 2003-04-09 | |||
JPH06503069A | 1994-04-07 | |||
JP2021506966A | 2021-02-22 | |||
JP2004503534A | 2004-02-05 | |||
JPS4943977A | 1974-04-25 |
Foreign References:
WO2002051799A1 | 2002-07-04 | |||
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WO2017140778A1 | 2017-08-24 | |||
WO2018015445A1 | 2018-01-25 | |||
WO2017189651A1 | 2017-11-02 | |||
WO2017189663A1 | 2017-11-02 |
Other References:
REGISTRY(STN)[ONLINE], JPN7023002888, 7 February 2018 (2018-02-07), pages 1 - 3, ISSN: 0005119336
LAPORTE M. G. ET. AL.: "TETRAHYDROBENZOTHIOPHENE INHIBITORS OF HEPATITIS C VIRUS NS5B POLYMERASE", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. VOL:16, NR:1,, JPN5021012077, 2006, NL, pages 100 - 103, ISSN: 0005119335
MAHESH T. CHHABRIA ET. AL.: "Discovery of novel Acyl Coenzyme A: Cholesterol Acyl transferase inhibitors: Pharmacophore-based vir", CHEMICAL BIOLOGY AND DRUG DESIGN, vol. 80, JPN6023030930, 2012, pages 107 - 113, ISSN: 0005119337
MCMANUS, J. M. ET AL.: "Sulfamylurea hypoglycemic agents. I. Synthesis and screening", JOURNAL OF MEDICINAL CHEMISTRY, vol. 8, no. 6, JPN6023030931, 1965, pages 766 - 76, XP002378748, ISSN: 0005119338, DOI: 10.1021/jm00330a009
SARGES, R. ET. AL.: "SULFAMYLUREA HYPOGLYCEMIC AGENTS. 6. HIGH-POTENCY DERIVATIVES", JOURNAL OF MEDICINAL CHEMISTRY, vol. VOL:19, NR:5,, JPN5021012081, 1976, US, pages 695 - 709, ISSN: 0005119339
ROBERT RONN; ET AL: "NEW DEVELOPMENTS IN THE DISCOVERY OF AGENTS TO TREAT HEPATITIS C", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 8, no. 7, JPN5021012086, April 2008 (2008-04-01), NL, pages 533 - 562, XP055636251, ISSN: 0005119340, DOI: 10.2174/156802608783955647
EDWARD H. WISEMAN ET. AL.: "Sulfamylurea hypoglycemic agents.II. Drug Dynamic Studies", JOURNAL OF MEDICINAL CHEMISTRY, vol. 8(6), JPN6023030932, 1965, pages 777 - 781, ISSN: 0005119341
LAPORTE M. G. ET. AL.: "TETRAHYDROBENZOTHIOPHENE INHIBITORS OF HEPATITIS C VIRUS NS5B POLYMERASE", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. VOL:16, NR:1,, JPN5021012077, 2006, NL, pages 100 - 103, ISSN: 0005119335
MAHESH T. CHHABRIA ET. AL.: "Discovery of novel Acyl Coenzyme A: Cholesterol Acyl transferase inhibitors: Pharmacophore-based vir", CHEMICAL BIOLOGY AND DRUG DESIGN, vol. 80, JPN6023030930, 2012, pages 107 - 113, ISSN: 0005119337
MCMANUS, J. M. ET AL.: "Sulfamylurea hypoglycemic agents. I. Synthesis and screening", JOURNAL OF MEDICINAL CHEMISTRY, vol. 8, no. 6, JPN6023030931, 1965, pages 766 - 76, XP002378748, ISSN: 0005119338, DOI: 10.1021/jm00330a009
SARGES, R. ET. AL.: "SULFAMYLUREA HYPOGLYCEMIC AGENTS. 6. HIGH-POTENCY DERIVATIVES", JOURNAL OF MEDICINAL CHEMISTRY, vol. VOL:19, NR:5,, JPN5021012081, 1976, US, pages 695 - 709, ISSN: 0005119339
ROBERT RONN; ET AL: "NEW DEVELOPMENTS IN THE DISCOVERY OF AGENTS TO TREAT HEPATITIS C", CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 8, no. 7, JPN5021012086, April 2008 (2008-04-01), NL, pages 533 - 562, XP055636251, ISSN: 0005119340, DOI: 10.2174/156802608783955647
EDWARD H. WISEMAN ET. AL.: "Sulfamylurea hypoglycemic agents.II. Drug Dynamic Studies", JOURNAL OF MEDICINAL CHEMISTRY, vol. 8(6), JPN6023030932, 1965, pages 777 - 781, ISSN: 0005119341
Attorney, Agent or Firm:
Ryoichi Takaoka
Nao Oda
Akiyo Iwahori
Rena Miyoshi
Kaoru Takahashi
Nao Oda
Akiyo Iwahori
Rena Miyoshi
Kaoru Takahashi
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