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Patent Searching and Data


Title:
NEW SULFURIC ACID ESTER DERIVATIVE
Document Type and Number:
Japanese Patent JPH05163234
Kind Code:
A
Abstract:

PURPOSE: To obtain a new sulfuric acid ester having action stimulating a β- adrenergic receptor or action inhibiting a platelet aggregation activation factor and useful as a medicine.

CONSTITUTION: A compound of formula I (R1 is OH or 1-6C alkyl; R2 is 1-8C hydrocarbon group) or pharmacologically permissible salt thereof, e.g. a pyridine salt of 6-benzyloxy-2-methylheptane-5-sulfate. The compound is obtained by converting a hydroxyl group of an unsaturated alcohol of formula II to an alkoxyl group, hydroboronating the double bond, successively oxidizing the compound to give a compound of formula III and reacting the compound of formula III with sulfone trioxide to carry out sulfuric acid esterification thereof.


Inventors:
KOSHIYAMA MASAMI
KIUCHI KOJI
Application Number:
JP35288891A
Publication Date:
June 29, 1993
Filing Date:
December 17, 1991
Export Citation:
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Assignee:
NIPPON ZEON CO
International Classes:
A61K31/255; A61P7/02; A61P9/00; A61P11/08; A61P25/02; A61P25/20; A61P29/00; A61P37/08; C07C305/10; (IPC1-7): A61K31/255; C07C305/10