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Title:
NEW TETRAHYDROPYRAN COMPOUND, ITS PRODUCTION, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
Document Type and Number:
Japanese Patent JPH0873484
Kind Code:
A
Abstract:

To obtain the subject new compound comprising a specific saccharic compound having a tetrahydropyran structure, having a vascularization-inhibiting ability and low toxicity and useful for treating diabetic retinopathy, chronic rheumatoid arthritis, hemangioma, solid tumor and the like.

A new tetrahydropyran compound represented by formula I [A is a group of the formula: OR6 (R6 is H, a 1-6C alkyl or a phenylalkyl); B is CH2X (X is OH, a halogen or the like), or forms oxirane or the like together with A; R1 is a group of formula II (Y and Z are each H, or Y and Z together form a double bond; R7 and R8 are each the same as R6); R2 is H, OH, a group of formula II or the like; R3 is H, a 1-6C alkyl, benzyl, benzoyl or the like; R4 is OH, a 1-6C alkoxy, carbamoyloxy or the like; R5 is H, or forms CO together with R4]. The compound is obtained by oxidizing β-D- fructopyranose of formula III, allowing the product to react with an alkenyl lithium of formula IV, and subsequently substituting the 3-hydroxyl group of the product by a hydrogen atom.


Inventors:
DEBITSUDO BIRINTON
JIRUBEERU DOREI
PASUKARU REON
GAANAMU ATASHII
ARAN PIEERU
MITSUSHIERU BIYURUBURITSUJI
NIKORA GIRUBOO
Application Number:
JP1995000221904
Publication Date:
March 19, 1996
Filing Date:
August 30, 1995
Export Citation:
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Assignee:
ADIR
International Classes:
C07H9/02; A61K31/70; A61K31/7028; A61P9/00; A61P29/00; A61P35/00; C07H9/04; C07H15/04; C07H15/10; C07H15/18; C07H15/26; (IPC1-7): C07H9/02; A61K31/70; C07H15/04; C07H15/18; C07H15/26
Attorney, Agent or Firm:
津国 肇 (外2名)