Title:
新規転写因子、その製法および用途
Document Type and Number:
Japanese Patent JP4789618
Kind Code:
B2
Abstract:
Ascochlorin or an analog or derivative thereof and a compound having a primary amino group are mixed and reacted with each other in the presence/absence of a basic catalyst to synthesize a novel imino compound. The novel imino compound thus synthesized is a ligand capable of activating nuclear receptor superfamily such as retinoid orphan receptor (RXR), peroxisome proliferator-activated receptor (PPAR) and steroid receptor (PXR), and shows an effect of promoting the transcription of a drug-metabolizing enzyme CYP7A1. The imino compound has a therapeutic effect on diseases such as lifestyle-related diseases, chronic inflammation and cancers.
Inventors:
Takeshi Kitahara
Hidenori Watanabe
Kunio Ando
Hidenori Watanabe
Kunio Ando
Application Number:
JP2005502807A
Publication Date:
October 12, 2011
Filing Date:
February 24, 2004
Export Citation:
Assignee:
Nrl Pharma Co., Ltd.
International Classes:
C07C249/02; A61K31/122; A61K31/19; A61K31/198; A61K31/223; A61K31/341; A61P3/06; A61P3/10; A61P7/10; A61P9/10; A61P9/12; A61P29/00; A61P35/00; C07C251/24; C07C403/18; C07D307/32
Foreign References:
| WO2000035867A1 | 2000-06-22 | |||
| WO2000053563A1 | 2000-09-14 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita