Title:
新しい三環式ジヒドロキノリン化合物、これらの製造方法及びこれらを含む医薬組成物
Document Type and Number:
Japanese Patent JP2004529191
Kind Code:
A
Abstract:
A compound of formula (I): wherein: represents a single or double bond, represents a ring system selected from R9a, R9b, R9c, X and Y are as defined in the description, R1 represents a group selected from hydrogen, aryl, heteroaryl, cycloalkyl, optionally substituted alkyl, and COR11, wherein R11 is as defined in the description, R2 to R8 each represent a group selected from hydrogen, halogen, hydroxy, polyhaloalkyl, nitro, optionally substituted alkyl, optionally substituted amino, optionally substituted alkoxy, -OPO(OH)2 and wherein m represents an integer such that 1<=m<4, or R2 with R3, or R3 with R4, or R4 with R5, form, together with the carbon atoms carrying them, an optionally substituted, mono- or bi-cyclic group optionally containing 1 or 2 hetero atoms, R16 represents a hydrogen atom or an alkyl group, represents an aryl, heteroaryl or aryl-alkyl group, its optical isomers, addition salts thereof with a pharmaceutically acceptable acid or base, and hydrates and solvates thereof.
Inventors:
Yousson, Henri-Philippe
Giorgi-Renault, Sylvianne
Debene, Stephanie
Ikman, John
Alain Pierre
Cross-Bertier, Laurence
Pfeiffer, Bruno
Renard, Pierre
Giorgi-Renault, Sylvianne
Debene, Stephanie
Ikman, John
Alain Pierre
Cross-Bertier, Laurence
Pfeiffer, Bruno
Renard, Pierre
Application Number:
JP2002591513A
Publication Date:
September 24, 2004
Filing Date:
May 22, 2002
Export Citation:
Assignee:
Réra Bora Toir Servier
International Classes:
A61K31/4741; A61K31/4743; A61K31/4745; A61K31/661; A61P35/00; C07D471/04; C07D491/04; C07D491/048; C07D491/056; C07D491/14; C07D497/04; C07F9/60; C07F9/6561; (IPC1-7): C07F9/60; A61K31/4741; A61K31/4743; A61K31/4745; A61K31/661; A61P35/00; C07D471/04; C07D491/048; C07D491/056; C07D497/04; C07F9/6561
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda