Title:
新規なウレアおよびチオウレア誘導体
Document Type and Number:
Japanese Patent JP5688367
Kind Code:
B2
Abstract:
The present application discloses compounds of formula (I) wherein X is ═O, ═S, ═NH, ═NOH and ═NO-Me; A is —C(═O)—, —S(═O)2—, —C(═S)— and P(═O)(R5)—; B is, —O—, —(CH2)3-6—, and O—(CH2)2-5—; D is, —O—, —CR7R8— and —NR9; m is 0-12, n is 0-12, m+n is 1-20; p is 0-4; R1 is opt.sub. heteroaryl; and pharmaceutically acceptable salts thereof, and prodrugs thereof. The application also discloses the compound for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT), e.g. inflammatory and tissue repair disorders; dermatosis; autoimmune diseases, Alzheimers disease, stroke, athersclerosis, restenosis, diabetes, glomerulonephritis, cancer, cachexia, inflammation associated with infection and certain viral infections, including Acquired Immune Deficiency Syndrome (AIDS), adult respiratory distress syndrome, ataxia telengiectasia.
Inventors:
メッテ・クナック・クリステンセン
フレドリク・ビイェルクリング
フレドリク・ビイェルクリング
Application Number:
JP2011524406A
Publication Date:
March 25, 2015
Filing Date:
August 31, 2009
Export Citation:
Assignee:
トポターゲット・アクティーゼルスカブＴｏｐｏＴａｒｇｅｔ Ａ／Ｓ
International Classes:
C07D213/40; A61K31/42; A61K31/4409; A61K31/4965; A61K31/505; A61K31/53; A61K31/5355; A61K31/5377; A61K31/664; A61P1/04; A61P11/08; A61P17/04; A61P17/06; A61P17/16; A61P19/02; A61P19/04; A61P19/10; A61P25/28; A61P29/00; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/06; A61P43/00; C07D213/75; C07D239/42; C07D241/20; C07D253/06; C07D261/14; C07D413/12; C07F9/58
Attorney, Agent or Firm:
Aoyama 葆
Yamada Takuji
Michiko Matsutani
Mitsuru Nishino
Masahiro Mizuhara
Yamada Takuji
Michiko Matsutani
Mitsuru Nishino
Masahiro Mizuhara