Title:
新規な置換インドリノン、それらの調製及び医薬組成物としてのそれらの使用
Document Type and Number:
Japanese Patent JP4015365
Kind Code:
B2
Abstract:
The invention relates to substituted indolinones of general formula (I), wherein R1 to R5 and X have the meanings given in claim 1, to their isomers and to their salts, especially their physiologically compatible salts. The inventive compounds have valuable pharmacological properties, especially an inhibitory effect on various kinases and cycline/CDK complexes, and on the proliferation of various tumour cells. The invention also relates to medicaments containing these compounds, to their use and to methods for producing them.
Inventors:
Heckel Armin
Walter Reinell
Greer Wolfgang
Van Mer Jacobs Zear
Redemann Norbert
Walter Reinell
Greer Wolfgang
Van Mer Jacobs Zear
Redemann Norbert
Application Number:
JP2000543432A
Publication Date:
November 28, 2007
Filing Date:
April 10, 1999
Export Citation:
Assignee:
Boehringer Ingelheim Pharma Gesellshaft Mitt Beschlenktel Haftung Und Company Comandito Gesellshaft
International Classes:
C07D209/34; A61K31/40; A61K31/403; A61K31/404; A61K31/4045; A61K31/4178; A61K31/4184; A61K31/422; A61K31/427; A61K31/4427; A61K31/4439; A61K31/454; A61K31/4709; A61K31/4725; A61K31/496; A61K31/5377; A61K31/541; A61K31/55; A61P35/00; A61P43/00; C07D401/12; C07D403/12; C07D413/12; C07D417/12
Domestic Patent References:
| JP9510993A |
Foreign References:
| WO1999015500A1 | ||||
| WO1996040116A1 |
Attorney, Agent or Firm:
Minoru Nakamura
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda
Fumiaki Otsuka
Sadao Kumakura
Shishido Kaichi
Hideto Takeuchi
Toshio Imajo
Nobuo Ogawa
Village shrine Atsuo
Takaki Nishijima
Atsushi Hakoda