Title:
眼神経変性障害（例えば緑内障）の処置及び予防における使用のためのニコチンアミド
Document Type and Number:
Japanese Patent JP7089469
Kind Code:
B2
Abstract:
The invention relates to the use of a pharmaceutical composition containing nicotinamide (NAM) and/or pyruvate as a neuroprotective medicament or gene therapy in the treatment of neurodegenerative disorders, in particular axon degeneration of neuronal tissue in ocular-related neurodegeneration diseases including glaucoma.
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Inventors:
John, Simon W. M
Williams, Peter Alexander
Williams, Peter Alexander
Application Number:
JP2018521064A
Publication Date:
June 22, 2022
Filing Date:
October 24, 2016
Export Citation:
Assignee:
THE JACKSON LABORATORY
International Classes:
A61K31/455; A61K31/137; A61K31/138; A61K31/19; A61K31/222; A61K31/27; A61K31/4168; A61K31/433; A61K31/4704; A61K31/475; A61K31/498; A61K31/5377; A61K31/5575; A61K31/706; A61K31/7084; A61K35/76; A61K35/761; A61K45/00; A61K48/00; A61P27/06; A61P43/00
Domestic Patent References:
| JP2005060397A | ||||
| JP2013530127A | ||||
| JP2010514517A |
Foreign References:
| US20050261234 | ||||
| WO2006079217A1 | ||||
| US20060211744 |
Other References:
OSBORNE NEVILLE N,PATHOGENESIS OF GANGLION "CELL DEATH" IN GLAUCOMA AND NEUROPROTECTION: FOCUS ON 以下備考,PROGRESS IN BRAIN RESEARCH,NL,2008年,VOL:173,PAGE(S): 339 - 352,DOI: 10.1016/S0079-6123(08)01124-2,GANGLION CELL AXONAL MITOCHONDRIA
Invest. Ophthalmol. Vis. Sci. (2013), 54, p.25-36
Curr. Opin. Ophthalmol. (2004), 15, p.132-135
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HEGDE K R,INHIBITION OF GLYCOLYSIS IN THE RETINA BY OXIDATIVE STRESS: PREVENTION BY PYRUVATE,MOLECULAR AND CELLULAR BIOCHEMISTRY,BO,KLUWER ACADEMIC PUBLISHERS,2010年06月18日,VOL:343, NR:1-2,PAGE(S):101 - 105,DOI: 10.1007/s11010-010-0503-9
PLoS Genet. (2005), 1(1): e4
J. Cell Biol. (2007), 179(7), p.1523-1537
BMC Ophthalmology (2012), 12:52
Invest. Ophthalmol. Vis. Sci. (2013), 54, p.25-36
Curr. Opin. Ophthalmol. (2004), 15, p.132-135
LI G,THE ROLE OF PARP-1 ON LIGHT-INDUCED APOPTOSIS OF CULTURAL RETINAL GANGLION CELLS,CHINESE OPHTHALMIC RESEARCH,中国,2008年11月,VOL:26, NR:11,PAGE(S):805 - 809
HEGDE K R,INHIBITION OF GLYCOLYSIS IN THE RETINA BY OXIDATIVE STRESS: PREVENTION BY PYRUVATE,MOLECULAR AND CELLULAR BIOCHEMISTRY,BO,KLUWER ACADEMIC PUBLISHERS,2010年06月18日,VOL:343, NR:1-2,PAGE(S):101 - 105,DOI: 10.1007/s11010-010-0503-9
PLoS Genet. (2005), 1(1): e4
J. Cell Biol. (2007), 179(7), p.1523-1537
BMC Ophthalmology (2012), 12:52
Attorney, Agent or Firm:
Shinjiro Ono
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Ichinomiya Ichinomiya
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Ichinomiya Ichinomiya
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