NITRO COMPOUND*ITS MANUFACTURE AND MEDICAL COMPOSITION CONTAINING IT

Japanese Patent JPS54157584

A

This invention concerns compounds showing activity as histamine H₂-receptor antagonists. The compounds of the invention are of Structurewhere Het is a substituted or unsubstituted, fully-unsaturated 5- or 6- membered heterocycle containing at least one nitrogen atom, or a furan or thiophene ring substituted by a substituted or unsubstituted aminoalkyl group; Z is sulphur, methylene or oxygen; m is 0, 1 or 2, n is 2 or 3 with m + n being 3 or 4; and B is a substituted or unsubstituted alkanediyl group or a 2-substituted-2-aza-1,3-propanediyl group; and acid addition salts thereof. The compounds of the invention can be prepared by reacting a compound of formula Het(CH₂)_mZ(CH₂)_nNH₂ or Het(CH₂)_mY (where Y is a group displaceable by a mercaptan) with an appropriate 2-subst)tuted-3-nitro-heterocyde. The compositions of the invention contain at least one compound of the invention and a pharmaceutical carrier.

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MIKAERU ROORENSU ROONTORII
RODONII KURISUTOFUAA YANGU

JP6739979A

December 12, 1979

May 29, 1979

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SMITH KLINE FRENCH LAB

A61K31/435; A61P43/00; C07D203/12; C07D207/24; C07D211/72; C07D337/14; C07D239/06; C07D403/12; C07D409/12; C07D417/12; (IPC1-7): A61K31/435; C07D401/12; C07D403/12; C07D413/12; C07D417/12

JPS5025565A

1975-03-18

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