Title:
炎症ベースの疾患用薬剤としてのニトロ誘導体
Document Type and Number:
Japanese Patent JP4451595
Kind Code:
B2
Abstract:
Use for the treatment of diseases having an inflammatory basis of compounds or salts thereof, Having the following general formula (I): A-X1-L-(W)p-NO2 wherein A contains the radical of a drug, X1 and W are bivalent radicals, L is a covalent bond or oxygen, sulphur, NR1e wherein R1e is H or a C1-C5 linear or branched alkyl.
Inventors:
Del Soldato, Clown
Benedini, Francesca
Antognazza, Patricia
Benedini, Francesca
Antognazza, Patricia
Application Number:
JP2002534255A
Publication Date:
April 14, 2010
Filing Date:
October 09, 2001
Export Citation:
Assignee:
NICOX S.A.
International Classes:
C07C317/44; C07D213/64; A61K31/21; A61K31/22; A61K31/222; A61K31/223; A61K31/235; A61K31/44; A61P1/00; A61P1/04; A61P1/16; A61P29/00; A61P35/00; C07C203/04; C07C233/25; C07C317/46; C07C323/60; C07C327/34; C07D213/30; C07D213/65
Domestic Patent References:
| JP11504906A | ||||
| JP11514636A | ||||
| JP9512798A | ||||
| JP9503214A | ||||
| JP8504191A | ||||
| JP7500355A | ||||
| JP9020738A | ||||
| JP2003515526A | ||||
| JP2002541233A |
Foreign References:
| WO2000051988A1 | ||||
| WO1998009948A1 |
Other References:
Chemical Abstracts,vol.129,abs.no.49318
al-Swayeh O.A., Futter L.E., Clifford R.H., Moore P.K.,Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity,British Journal of Pharmacology,2000年,130,1453-1456
Wenk, G. L.; McGann, K.; Mencarelli, A.; Hauss-Wegrzyniak, B.; Del Soldato, P.; Fiorucci, S.,Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons,European Journal of Pharmacology,2000年,402(1/2),77-85
Bing, Richard J.; Yamamoto, Tadahiko; Kim, Hyunjin; Grubbs, Robert H.,The Pharmacology of a New Nitric Oxide Donor: B-NOD,Biochemical and Biophysical Research Communications,2000年,275(2),350-353
al-Swayeh O.A., Futter L.E., Clifford R.H., Moore P.K.,Nitroparacetamol exhibits anti-inflammatory and anti-nociceptive activity,British Journal of Pharmacology,2000年,130,1453-1456
Wenk, G. L.; McGann, K.; Mencarelli, A.; Hauss-Wegrzyniak, B.; Del Soldato, P.; Fiorucci, S.,Mechanisms to prevent the toxicity of chronic neuroinflammation on forebrain cholinergic neurons,European Journal of Pharmacology,2000年,402(1/2),77-85
Bing, Richard J.; Yamamoto, Tadahiko; Kim, Hyunjin; Grubbs, Robert H.,The Pharmacology of a New Nitric Oxide Donor: B-NOD,Biochemical and Biophysical Research Communications,2000年,275(2),350-353
Attorney, Agent or Firm:
Shintaro Nogawa