Title:
ドーパミンＤ３受容体拮抗作用を有する含窒素縮環化合物
Document Type and Number:
Japanese Patent JP7015092
Kind Code:
B2
Abstract:
Novel compounds having D3 receptor antagonistic activity are provided. A compound represented by formula (I):whereinring A is a heterocycle, Xis each independently CRR, Xis each independently CRR, Yand Yare each independently a carbon atom or a nitrogen atom,L is -N(R)-C(=O)- or the like, W is cyclyl or the like, Rand Rare each independently substituted or unsubstituted alkyl or the like, R, R, Rto R, and Rare each independently hydrogen atoms or the like,p is 1 or 2, q is an integer of 1 to 3, n is an integer of 1 to 4, s is an integer of 0 to 4, or a pharmaceutically acceptable salt thereof.
Inventors:
Hiroyuki Tobinaga
Koji Masuda
Satoshi Kasuya
Inagaki Masahisa
Mitsuhiro Yonehara
Manami Masuda
Koji Masuda
Satoshi Kasuya
Inagaki Masahisa
Mitsuhiro Yonehara
Manami Masuda
Application Number:
JP2018530371A
Publication Date:
February 02, 2022
Filing Date:
July 27, 2017
Export Citation:
Assignee:
Shionogi Pharmaceutical Co., Ltd.
International Classes:
C07D471/04; A61K31/437; A61K31/444; A61K31/4545; A61K31/4709; A61K31/4725; A61K31/4985; A61K31/501; A61K31/502; A61K31/5025; A61K31/506; A61K31/519; A61K31/5377; A61K31/55; A61P25/00; A61P25/16; A61P25/18; A61P25/20; A61P25/22; A61P25/30; A61P43/00; C07D487/04; C07D513/04; C07D513/08; C07D519/00
Domestic Patent References:
| JP9506346A | ||||
| JP2008537741A | ||||
| JP2012509856A | ||||
| JP2010534665A | ||||
| JP2008502581A | ||||
| JP2001517301A | ||||
| JP2002522366A | ||||
| JP2002528437A | ||||
| JP2002527433A | ||||
| JP2002527432A |
Other References:
MACH, U.R. et al.,Development of novel 1,2,3,4-tetrahydroisoquinoline derivatives and closely related compounds as pot,ChemBioChem,2004年,Vol.5, No.4,pp.508-518
Attorney, Agent or Firm:
Kenichi Sugita
Hideaki Watanabe
Hideaki Watanabe
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