Title:
NITROGEN-CONTAINING TRI-OR TETRACYCLIC COMPOUND AND ANTIVIRAL AGENT CONTAINING THE SAME COMPOUND
Document Type and Number:
Japanese Patent JPH11199565
Kind Code:
A
Abstract:
To obtain the subject medicine such as antiherpes viral agent exhibiting excellent antiviral activity and useful as a medicine by including a specific nitrogen-containing tri or tetracyclic compound.
This antiviral agent contains a nitrogen-containing tri or tetracyclic compound of formula I [R1 is a (substituted)alkyl or the like; R2 is a (substituted)aryl or the like; R3 is H or the like; R4 is H or the like; A1 or A2 is N or the like; A3 is CH or the like] or its salt [e.g. 2-fluoro-10- methyl-6-(pyridin-4-yl)-9,10-dihydro-9-acylidinone or the like]. The antiviral agent is administered at a daily dose of 0.1-100 mg/kg.adult once or in several portions. The compound of formula I is obtained by subjecting a compound of formula II (X is a leaving group) to coupling reaction with a tin compound of the formula R2-Sn (Alk)3 (Alk is a lower alkyl) in the presence (or absence) of silver oxide and in the presence of a palladium catalyst.
Inventors:
FURUTA YOSUKE
SUGITA ATSUSHI
UEHARA SAYURI
TAKAHASHI KAZUMI
NAGAKI HIDEYOSHI
KANNA HIROSHI
SHIRAKI KIMIYASU
Application Number:
JP29433998A
Publication Date:
July 27, 1999
Filing Date:
October 16, 1998
Assignee:
TOYAMA CHEMICAL CO LTD
International Classes:
A61K31/00; A61K31/435; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/47; A61K31/473; A61K31/495; A61K31/505; A61K31/506; A61K31/535; A61K31/5375; A61K31/5383; A61K31/70; A61K31/7042; A61K31/7052; A61K31/706; A61P31/00; A61P31/12; A61P31/22; C07D401/04; C07D405/06; C07D405/14; C07D409/04; C07D409/14; C07D413/04; C07D413/14; C07D219/06; C07D417/04; C07D417/14; C07D471/04; C07D471/14; C07D487/04; C07D487/06; C07D487/14; C07D491/06; C07D498/06; C07F9/6561; C07H19/04; (IPC1-7): C07D219/06; A61K31/00; A61K31/435; A61K31/44; A61K31/47; A61K31/495; A61K31/505; A61K31/535; A61K31/70; C07D401/04; C07D405/06; C07D405/14; C07D409/04; C07D409/14; C07D413/04; C07D413/14; C07D417/04; C07D417/14; C07D471/04; C07D471/14; C07D487/04; C07D487/06; C07D487/14; C07D491/06; C07D498/06; C07F9/6561; C07H19/04
Domestic Patent References:
| JPH08151368A | 1996-06-11 | | | |
| JPH08151368A | 1996-06-11 | | | |
Foreign References:
| US4244954A | 1981-01-13 | | | |
| US4244954A | 1981-01-13 | | | |
Other References:
JPN6009020330, Ｊｏｕｒｎａｌ ｏｆ ｔｈｅ Ａｍｅｒｉｃａｎ Ｃｈｅｍｉｃａｌ Ｓｏｃｉｅｔｙ, 1954, ７６, １２７６−１２７８
JPN6009020333, Ｊｏｕｒｎａｌ ｏｆ Ｍｅｄｉｃｉｎａｌ Ｃｈｅｍｉｓｔｒｙ, 1992, ３５（１５）, ２７４４−５２
